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56 articles for “Parkinson disease”
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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An overview on the diagnosis and approaches in pharmacological management of Parkinson’s disease
Abstract: Parkinson’s disease (PD) might be a mutual neurodegenerative disease considered by a movement disorder containing rest tremor, bradykinesia, rigidity, and postural instability, and second-leading reason of dementia and is categorized by an advanced loss of dopaminergic neurons within the neural structure alongside the occurrence of intraneuronal α-synuclein-positive enclosures. PD is identified where bradykinesia happens along with rigidity or tremor within the existence of supporting features. The diagnosis is clinical, and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 1, 2021 · pp. 1–8 Read article
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A General Review of Mucuna Pruriens W.S.R to its effect on Parkinson’s Disease.
Abstract: Mucuna Pruriens is a very famous drug prescribed in classical ayurvedic science in various disorder of Nervous System including Kampavata .In Clinical Practice ,Physician used Levadopa as a Dopamine replacement agent in controlling bradykinetic symptoms apparent in Parkinson disease so used successfully in treatment of Parkinson disease.Kapikacchu(Mucuna Pruriens) is having Balya, Brimhanaha, Vrishya, and Vatahara properties and is a natural source of L-dopa. So, keeping in views of the degenerative …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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An Open Clinical Study to Evaluate the Efficacy of Shirobasti and Nasya with and without Levodopa in the Management of Kampavata w.s.r. to Parkinson’s Disease (PD)
Abstract: Background: Kampavata (Parkinson’s disease), considered as Vata Nanatamaja disorder, is the most common progressive neurodegenerative disorder characterized by bradykinesia, resting tremors, muscular rigidity, shuffling gait and flexed posture accompanied by a variety of non-motor symptoms, including autonomic, sensory, sleep, cognitive and psychiatric disturbances. Aim and Objectives: To study the effect of Shirobasti and Nasya in the management of Kampavata (PD) with levodopa and without levodopa. Materials and Methods: The present …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 8, Issue 3, 2021 · pp. 15–28 Read article
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Exploring the Complexities of Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurological disorder, primarily affecting older adults, marked by both motor and non-motor symptoms. This review explores PD as a multisystem disorder that influences the central, enteric, and autonomic nervous systems, along with the immune system and gastrointestinal tract. Key pathogenic features include the degeneration of dopamine-producing neurons in the substantia nigra and the formation of Lewy bodies containing misfolded α-synuclein proteins. The bradykinesia, tremors, stiffness, …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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In vivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats
Abstract: Elegant research has shown that plants are useful for both curative and preventive purpose on the humans populous. Prevalent among diseases associated with humans are neurological diseases which affect a large sector of the population especially the elderly. The most common neurological diseases are Parkinson and Alzheimer disease which affect a large sector of the brain and also cause an imbalance in brain electrolyte. Among such electrolytic mechanisms of the …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 31–36 Read article
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A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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Effect of Neuromuscular Electrical Stimulation (NMES) on the Measures of Hyolaryngeal Elevation during Swallow in Individuals with Parkinson’s Disease
Abstract: Inadequate hyolaryngeal elevation is one among the leading cause of aspiration and dysphagia in individuals with Parkinson’s disease. Treatment protocols specific in strengthening the hyolaryngeal elevation are seldom studied in this population. Neuromuscular Electrical Stimulation (NMES) for swallow is a recent technical advancement in the arena of dysphagia rehabilitation that targets on stimulating the laryngeal extrinsic and the suprahyoid muscles, responsible for adequate movements of the hyolaryngeal complex. The literature …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 2, 2022 · pp. 18–25 Read article
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Discernment of Parkinson’s disease using Machine learning
Abstract: Parkinson’s disease is one of the most common neurological disorders in the world that is caused when the cells in the brain that are responsible for the creation of dopamine breakdown and as a result less dopamine is produced .The cells in the brain that create dopamine are in charge of movement regulation, adaptability, and fluency. Since researchers believe that the disease starts developing many years before the motor (movement-related) …
Published in Journal of Microcontroller Engineering and Applications · Vol. 9, Issue 2, 2022 · pp. 14–19 Read article
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Identification of the Effects of Brain Stimulation on Neurophysiology in Parkinson’s Disease Patients: Systematic Review
Abstract: Parkinson’s disease (PD) is after Alzheimer’s disease the most common progressive neurodegenerative disease with prevalence of 150–200/100000. Etiology is not well known except for inheritance. It is associated with various neurophysiologic disorders. The aim is to concise view of various studies about the relation between the brain stimulation either unilateral or bilateral and subthalamic or pallidal on gait patterns, speech defects, cognition, behavior changes, mood swings, tremors and memory. This …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 1, 2014 · pp. 17–22 Read article
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Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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Parkinson’s Disease Detection on Spiral Images Using CNN with Meta-Classifiers
Abstract: In this work, we provide a detailed method for identifying Parkinson’s Disease (PD) by integrating Convolutional Neural Network (CNN) and meta-classifiers. Through the utilization of a varied dataset consisting of handwritten spiral images, our methodology demonstrates commendable accuracy across a range of models. Specifically, our CNN model with meta-classifiers surpasses alternative approaches, achieving an impressive accuracy rate of 95.07%. By utilizing pre-established VGG16 and ResNet50 architectures as bases, the region-based …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 1, 2025 · pp. 55–66 Read article
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Pseudodysphagia in a Person with Parkinson’s Disease: A Case Report
Abstract: Pseudodysphagia is a psychosomatic fear of choking and is an unusual type of dysphagia encountered by a Speech Language and Swallow Pathologist (SLP). The patients presenting this illness are afraid of swallowing as they fear that swallowing will lead to choking. The assessment and rehabilitation of pseudodysphagia is challenging and requires an SLP to work with a multidisciplinary team comprising An SLP, Psychologist, Neurologist, ENT specialist, Radiologist, Gastroenterologist, and a …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 3, 2021 · pp. 15–21 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 52–58 Read article
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Machine Learning-Based Disease Prediction: A Comparative Analysis for Diabetes, Brain Tumor, and Parkinson's Disease
Abstract: This paper presents a web-based disease prediction system that integrates machine learning and deep learning techniques to assist in the early detection of Parkinson’s Disease, Diabetes, and Brain Tumors. By utilizing clinical data and MRI images, the platform provides rapid and interpretable predictions to support proactive health management. Logistic Regression models are applied to classify structured datasets for predicting Parkinson’s disease and Diabetes, making use of their effectiveness in binary …
Published in Current Trends in Signal Processing · Vol. 15, Issue 2, 2025 · pp. 44–54 Read article
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Stem Cell Therapy for Parkinson's Disease: Past, Present and Future
Abstract: Parkinson’s disease (PD) is one of the most common chronic progressive nervous system disorders of aging. Cell degeneration and death of dopamine neurons (DA neurons) in the substantial nigra, is the underlying feature of PD. Genetic studies showed much about the physiological processes associated with this disease. Replacing the cells lost by injury or disease has become a central idea aiming at the development of novel therapy for neurodegenerative diseases. …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 1, 2019 · pp. 1–12 Read article
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Parkinson’s Diagnosis and Differential Diagnosis: A Review
Abstract: Parkinson’s disease is a progressive degenerative disorder of the cerebellum occurs in all ethnic groups has an equal sex distribution. It is characterized by slowly progressive akinesia, rigidity, postural abnormality, and resting tremor. Because of its crippling nature and non-availability of curative treatment, Parkinson’s disease has remained a great problem. Though in modern medical science a lot of research works have been done. Some medication like Carbidopa, Levodopa, recently some …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 1, 2021 · pp. 37–44 Read article