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834 articles
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A Pilot Study on β-lactamase Producing Escherichia coli from Bovine Milk, West Bengal
Abstract: Drug resistant bacteria have become a significant global healthcare issue that requires close attention. With regards to antibiotic resistance, E.coli and its Enterobacteriaceae family are highly notorious for their ability to swiftly spread antibiotic resistance genes, thereby posing a major concern. In order to effectively address the spread of multi drug resistant bacteria, ongoing monitoring of the microflora in milk for the presence of drug resistant genes is essential. This …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 01–05 Read article
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Rheumatoid Arthritis and its Relationship with Vitamin D, ESR, and Obesity
Abstract: Recent years have seen a rise in the prevalence of rheumatoid arthritis (RA), a disease marked by the destruction of articular cartilage and ankylosis of the joints, as well as other complications such as diffuse lung inflammation, sclera, pleura, pericardium, and nodular lesions, which are also common in subcutaneous tissue. Reviewing RA symptoms, diagnosis, treatment, and associations with vitamin D, ESR, and obesity was the aim of the study. Even …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 06–12 Read article
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Tools, Modern Drugs, and Latest Investigations for the Diagnosis and Treatment of Heart Failure: A Systematic Review of the General Causes
Abstract: Heart failure (HF) diagnosis and treatment present formidable challenges, given the absence of a definitive single test. This systematic literature review aims to comprehensively analyze the current landscape of diagnostic tools, modern drugs, and latest investigative approaches in HF management. Recognizing the complexity of HF etiology, this systematic review emphasizes the importance of advanced diagnostic methods, such as genetic testing and artificial intelligence applications. The systematic review was conducted to …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–10 Read article
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A Study to Assess the Knowledge of Mothers Regarding Nutritional Status of Under Three- Years at Selected Urban Areas at Sankeshwar
Abstract: Background of the study: Solid knowledge of maternal/caregiver nutrition serves as a safeguard against factors that result in low weight-for-age z-score and low height-for-age z-score in children. The historical trend has shown that indicators of favorable child nutritional status have typically been lower in urban regions due to the prevalence of working mothers. Objectives: To assess the knowledge of mothers regarding nutritional status of child Methods: This research adopted a …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 1, 2024 · pp. 1–6 Read article
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A review on antibacterial properties of eucalyptus oil and different eucalyptus species used in pharmaceuticals
Abstract: Medicinal plants with antimicrobial compounds play a crucial role in combating various pathogens. Eucalyptus, belonging to the myrtle family, is notable for its diverse antimicrobial compounds. This fast-growing plant thrives in many countries and its various parts offer significant medicinal value, including timber, pulpwood, and essential oils. The leaves, often considered forest harvesting waste, contain essential oils with potential medicinal benefits. Members of the genus Eucalyptus are highly valued for …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 10–19 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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Evaluation of Prescribing Pattern of Drugs in Hemodialysis Patients
Abstract: Background: Patients undergoing hemodialysis often exhibit a high level of dependency and frequently present with multiple co-morbid conditions Chronic kidney disease (CKD) poses a significant global public health challenge, with its association with numerous complications. Prescribing medications appropriately for individuals with CKD presents a substantial challenge. Objective: The study aimed to assess the prescribing patterns of drugs in hemodialysis patients. Results: Out of the total 82 selected patients, 42 (51%) …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 20–26 Read article
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Assessment of Finerenone Safety and Efficacy in Individuals with Type 2 Diabetes and Chronic Kidney Disease
Abstract: Background: In this work, we provide strong evidence for the safety and efficacy of finerenone in people with type 2 diabetes and chronic kidney disease. Our goal is to improve patients' quality of life and general well-being through our research. Aim: Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 06–09 Read article
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Antibiotics – Challenges in our Post-COVID Era
Abstract: Accidental discovery of the antibiotic properties of penicillin marked a watershed moment in healthcare, transforming the landscape of medicine and saving countless lives of injured and infected. Further research and awareness on the advantages of this “miracle drug” resulted in its bulk production in the 1940s, and played a crucial role in saving lives of thousands during World War II. Subsequent discoveries especially broad-spectrum antibiotics paved the way for further …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 1–5 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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“DEVELOPMENT AND CHARACTERIZATION OF PHYTOSOMES FOR THE TREATMENT OF ANTI-CANCER ACTIVITY BY USING THE Spirulina (Arthospira Plantesis) EXTRACT”
Abstract: This study aims to investigate and evaluate spirulina's anticancer properties.The current research is centred on obtaining a Spirulina-containing drug. The goal is to design and create Phytosomes, characterizing them based on relevant and crucial parameters. The process of solvent evaporation was utilized in the creation of Phytosomes. Various parameters such as zeta potential, particle size, infra-red spectral analysis, % drug content, encapsulation efficiency, and % drug release (% DR) were …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 10–22 Read article
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Environmental implications of Chitosan nanostructures.
Abstract: Chitosan (CS), as a biopolymer, has unrivalled chemical and mechanical modification capabilities to develop novel characteristics, functions, and applications, particularly in the manufacture of cutting-edge membrane adsorbents. Membrane adsorbents utilizing carbon starch (CS) have emerged as a viable and efficient engineering instrument for eliminating diverse pollutants from aquatic settings, including heavy metals and dyes. To date, much study has been directed towards improving the adsorptive characteristics, permeability, physicochemical stability, and …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 42–58 Read article
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A Concurrent Estimation of Phytoconstituents Piperine, Quercetin and Kaempferol Present in Siddha Polyherbal Formulation Kabasara Kudineer by Rp-Hplc
Abstract: A straightforward, accurate, and precise technique was developed and validated for the simultaneous determination of Quercetin, Kaempferol, and Piperine in the polyherbal formulation Kabasura Kudineer. The sample was chromatographed using a C18 column (150x4.6mm, 5u) with a mobile phase composed of Acetonitrile and Ortho phosphoric acid in a 45:55 ratio, flowing through the column at a rate of 1ml/min. The detection wavelength for Quercetin, Kaempferol, and Piperine was set at …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 1–9 Read article
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Unresolved and misdiagnosed of floating sensation in young man
Abstract: Persistent Postural-Perceptual Dizziness (PPPD) stands out as a prevalent peripheral vestibular disorder, earning its recognition in the International Classification of Vestibular Disorders in 2017. Characterized by chronicity, this condition manifests symptoms persisting for more than three months, encompassing a disconcerting array such as a floating sensation, unsteadiness, and dizziness. Notably, individuals afflicted with PPPD often report symptom exacerbation following prolonged standing, self-initiated motion, or exposure to dynamic visual stimuli. This …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 1–4 Read article
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Risk & Opportunities in Development of new Drugs: A New Perspective
Abstract: The procedures of drug discovery and development are briefly described in this article. Our goal is to assist researchers whose work may be pertinent to the discovery and/or development of new drugs in framing their research reports in a way that appropriately situates their findings within the drug discovery and development process and supports the efficient translation of preclinical research to humans. One overarching theme of our article is the …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Bioethanol and Beyond: A Comprehensive Review on Sustainable Biofuels for Global Energy Demands and Environmental Conservation
Abstract: This comprehensive review explores the concept of "biofuels," specifically focusing on energy-enriched chemicals generated through biological processes or derived from the biomass of living organisms, including microalgae, plants, and bacteria. As the global population continues to increase, there is a growing demand for more energy supplies to enhance the quality of life. Biofuels, harnessed from various sources such as sugar, starch, and organic waste, have emerged as potential solutions to …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 1–9 Read article
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Dengue in India : Insights in the Indian Context
Abstract: The mitigation of infectious diseases in India, notably Dengue, assumes pivotal importance due to their significant repercussions on human and animal health, thereby imposing a considerable burden on the healthcare infrastructure. This review underscores the ongoing initiatives in infectious disease management, endorsing the implementation of a comprehensive healthcare strategy. Emphasis is placed on the augmentation of reporting mechanisms through the integration of IgM detection kits, advocating for heightened investments in …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 10–13 Read article
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Isolation and Evaluation of Aspergillus Niger : A Fungi Implicated in Infectious Diseases and its application as potential Biofertilizer
Abstract: In the quest to improve the agronomic effectiveness of Rock Phosphate (RP), a widely available and cost-effective phosphate fertilizer, this study aimed to overcome its limited solubility by isolating fungal strains capable of solubilizing rock phosphate. Soil samples were collected from Garhmukteshwar, Hapur, for the isolation process. Among several isolates, three strains exhibited the highest rock phosphate solubilization within a seven-day timeframe, coinciding with a significant decrease in soil pH. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 29–34 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article