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834 articles
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Exploring the Thyroid Gland Physiology in Relation to Thyroid Hormones: An Overview through the Lens of 3D Computational Biology
Abstract: The endocrine system plays a pivotal role in orchestrating and sustaining diverse physiological functions by manufacturing and releasing hormones, which function as vital chemical messengers within the body. Among the prominent endocrine glands, the thyroid gland holds a central position. Situated in the lower part of the neck, this gland adopts a butterfly-shaped structure. Its significance lies in the synthesis of three key hormones: thyroxine (T4), tri-iodothyronine (T3), and calcitonin.The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 46–54 Read article
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Vyanga, Present-Day Challenge: Insights from Toxicological Standpoint
Abstract: The condition of Vyanga can have significant repercussions, as facial disfigurement not only impacts an individual's psychological and social well- being but also hampers their overall contribution to society. This can result in reduced productivity, impaired social functioning, and diminished self-esteem. In classical Ayurvedic texts, Vyanga is categorized under Kshudrarogas, representing minor disorders with straightforward causes and symptoms. However, in certain instances, these conditions can lead to noticeable cosmetic impairments, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 11–16 Read article
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Wave plate; what is the angle of its central curved segment which provides biomechanically optimal stability for femoral shaft fracture?:A 3-D Finite Analysis
Abstract: Even though intramedullary nailing of femoral shaft fracture is the standard surgical treatment as it is in tibial fracture, plate fixation might be a choice when the fracture involves open growth plate, patients are of shorter stature or have narrow canals. In these cases, fixation techniques with plate and screws, for example, percutaneous procedures involving wave plate, are useful thanks to minimal invasion and preservation of biological environment surrounding the …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 31–43 Read article
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Embryonic Advancement: An Overview from a Surgical Perspective
Abstract: The fertile ground of a mother& body serves as the nurturing environment where the seed of life can thrive, ensuring that it receives the necessary nutrients to burgeon into a robust and resilient offspring. A well-nourished mother possesses the capacity to furnish her developing fetus with all essential requirements, simultaneously building up reserves to support ample breastfeeding postpartum. This dual focus on maternal nutrition not only aims for optimal fetal …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 19–24 Read article
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Role of Dried Allogenic Amniotic Membrane in Second degree Scald Burns
Abstract: Burn injuries represent a significant portion of common injuries, stemming from thermal, scalding, or electrical incidents. Among these, scald injuries stand out as the predominant type in children under five years old, constituting a majority, with over 65% of cases falling under this category. Currently, various scaffolds are employed to enhance the healing process and mitigate scar formation. Collagen plays a crucial role as a scaffold, facilitating tissue regeneration and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 25–30 Read article
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Role of JIPMER Burn Progress Proforma
Abstract: Burn injuries represent a significant contributor to mortality rates in developing nations such as India. While critical care ICUs commonly utilize progress proformas, those specifically tailored for burns are less prevalent. Recognizing this gap, a modified burn progress proforma has been developed to encompass comprehensive details for both acute management and rehabilitation strategies. In a country like India, where burns can have severe consequences, the need for a specialized progress …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 6–10 Read article
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Innovative Use of Pressure Relieving Foam Based Garment for Lumbar Pressure Sore
Abstract: Pressure ulcers, stemming mainly from friction and shear forces, manifest as chronic wounds that worsen over time. They commonly afflict individuals who are bedridden or have limited mobility. Our investigation involved a 62-year-old male with a hypertrophic scar on his back resulting from the excision of a carbuncle. Subsequently, he developed a lumbar pressure sore at the scar site. To address this issue, adjustments were made to his pressure garment, …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 52–56 Read article
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Sugar Substitutes: Benefit or Burden
Abstract: The ubiquitous presence of sugar in our daily diet poses a considerable impact on both dental and overall health. The consensus is clear: an excess of sugar is far from ideal. Moreover, controversial conjectures have emerged, suggesting a pivotal role of excessive sugar intake in certain degenerative diseases. In response to these concerns, artificial sweeteners, also known as sugar substitutes or low-calorie sweeteners, have become increasingly appealing to consumers.Artificial sweeteners, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 7–11 Read article
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Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
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Drug abuse in Teenagers
Abstract: Teenage drug abuse is a significant public health concerns with far - reaching consequences. This abstract provides on overview of the prevalence, contributing Factor and consequences of drug abuse among adolescents. Drug abuse remains persistence and multifaceted issue globally, affecting individual’s families and society. Factors that influence the teenagers to experiment with drugs, including peer pressure, family dynamics and predisposition. The abstract also describes the various substance abused by teenagers, …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 15–25 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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Adr Caused Byanti-Snake Venom a Case Report Highlighting the Pathophysiology, Prevention, and It’s Management
Abstract: Even in situations where it wasn't necessary, antivenom research was applied to snake bite cases. In order to improve their level of understanding, primary practitioners should receive training on handling envenomation situations as well as current recommendations and references. In cases of snake bites, antivenom must be delivered according to applicable systemic and original indications.More than ten percent of cases with admitted ASV experience some sort of reaction, ranging from …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 40–46 Read article
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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A Rare Case Of Symplastic Leiomyoma Of Uterus : A case Report
Abstract: Uterine smooth muscle tumors (USMT) are of mesenchymal origin and develop from the smooth muscle cells of the uterus. Leiomyomas and their subtypes are the most commonly occurring USMT’s. Symplastic Leiomyoma is an unusual histologic subtype of Benign Leiomyoma, hence also known as atypical or Bizarre leiomyoma. It is often difficult to differentiate it from Leiomyosarcoma because of its bizarre looking nuclei on histology. However it’s malignant transformation is rare. …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 26–31 Read article
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Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Coronary Vascular Disease: A General Review with Specific Reference to Etiology
Abstract: Cardiovascular disease (CVD), the foremost cause of mortality worldwide, has surged by 60% globally, reaching 20.5 million deaths in 2021 from 12.1 million in 1990, as per the latest report from the World Health Federation. While this increase is alarming on a global scale, it raises even greater concerns in countries like India where heart ailments are afflicting individuals at a younger age. The escalation of CVD among the younger …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 36–42 Read article
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Overview of Virulence Factor of Staphylococcus sp.
Abstract: Staphylococcus is a highly virulent genus of bacteria that can cause a range of infections in humans and animals. The production of toxins, enzymes, and biofilms contributes to its ability to establish infections and evade host defenses. Understanding the characteristics and virulence factors of Staphylococcus is crucial for the development of effective prevention strategies and treatment options. Staphylococcus aureus is a significant etiological agent of nosocomial infections on a global …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 25–31 Read article
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Development of an Environmentally Friendly Bioplastic Film Derived from Water Hyacinth
Abstract: The water hyacinth, an invasive aquatic plant negatively impacting ecosystems, serves as a promising source for raw materials in the production of carboxymethylcellulose (CMC)-based bioplastics due to its high cellulose concentration. This initiative not only mitigates water hyacinth pollution in natural water resources but also contributes to the reduction of plastic waste through the creation of biodegradable CMC bioplastic films. The cellulose extraction from water hyacinth precedes the synthesis of …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 18–24 Read article
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A Rare Case of Serous Cystadenoma Ovary with Cholesterol Granuloma in an Adult Female
Abstract: In reaction to cholesterol crystals and foreign body giant cells, cholesterol granulomas are formed. These are the results of long-term inflammation brought on by the buildup of cholesterol crystals in tissues. The middle ear and paranasal sinuses are the most often reported locales; however, the mediastinum, breast, and ovary have all been implicated in a small number of cases. Here, we report a rare instance of an accidental ovarian cholesterol …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 13–17 Read article