Volume 9, Issue 1 (2022)
Published
Table of contents
-
Antidiabetic Activity of Triazole Derivatives: A Review
Abstract: Triazoles are the most commonly synthesized nitrogen containing hetero cyclic compounds which have a numerous biological activity viz. antifungal, antimicrobial, anthelmintic, anticancer, anti-tubercular and antiviral activities. They are 5-membered hetero ring structure containing nitrogen as heteroatom at 3 positions. Over a decade, studies are being focused on the anti-diabetic activity of 1,2,3-triazole and 1,2,4-triazole derivatives. Diabetes mellitus is a disorder in which the body doesn't produce enough insulin or does …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 1–20 Read article
-
A Review of the Cardioprotective Effects of Plant Derived and Synthetic Derivatives Targeting the Cannabinoid Receptors
Abstract: Cannabinoids are chemicals that were discovered in the Cannabis sativa plant for the first time. They've been used to treat a variety of ailments for thousands of years. The endocannabinoid system is made up of cannabinoid receptors, endocannabinoids, and the enzymes that catalyse their synthesis and breakdown. It plays a vital role in cardiovascular system function. The findings so far point to endocannabinoids playing a role in the pathogenesis of …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 21–38 Read article
-
Microneedles: A Potential Drug Delivery System for the Treatment of Cancer
Abstract: Hypodermic needles, topical lotions, and transdermal patches are the most common methods for transdermal drug administration. Most medicinal drugs have a limited effect due to the stratum corneum layer of the skin, which acts as a barrier for molecules, allowing only a few molecules to reach the site of action. Microneedles are a novel type of delivery method that helps to improve medication administration through this route while also solving …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 39–61 Read article
-
Design and Evaluation of Itraconazole Niosomes
Abstract: The present study was undertaken with an aim to fabricate and characterize and evaluate niosomes of Itraconazole, where the drug is released in a sustained manner for a period of 12 hours. Itraconazole is Class-2 drug having low solubility and have short half-life between 3–4 hours. Due to high first pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained release delivery. To overcome these …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 62–68 Read article
-
Method Development and Validation for Estimation of Brisoprolol Fumerate by UV Spectrometric Method using 0.01N HCl as Solvent
Abstract: The objective of the present work is to develop a new, simple, economical, precise, sensitive, linear, accurate, rapid UV Spectrophotometeric method has been developed, solvent used 0.1 N HCl, for the estimation of Brisoprolol Fumerate bulk and pharmaceutical formulation as per ICH guidelines. Spiked Brisoprolol Fumerate arrangement was checked over UV-visible extend for its wavelength of greatest absorbance. The wavelength of most extreme absorbance for Brisoprolol Fumerate was found to …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 69–74 Read article