STM Journals Peer-reviewed research from Consortium e-Learning Network

Trends in Drug Delivery

A Review of the Cardioprotective Effects of Plant Derived and Synthetic Derivatives Targeting the Cannabinoid Receptors

  1. Shailaja Shashikant Shirsat
  2. Sameer N. Goyal

Abstract

Cannabinoids are chemicals that were discovered in the Cannabis sativa plant for the first time. They've been used to treat a variety of ailments for thousands of years. The endocannabinoid system is made up of cannabinoid receptors, endocannabinoids, and the enzymes that catalyse their synthesis and breakdown. It plays a vital role in cardiovascular system function. The findings so far point to endocannabinoids playing a role in the pathogenesis of a variety of cardiovascular illnesses, including myocardial infarction, hypertension, and hypotension linked to hemorrhagic, endotoxic, and cardiogenic shock. The cardioprotective effects of endocannabinoids, as well as the dilatation of coronary arteries caused by them, require special attention. It is impossible to rule out the possibility that a greater understanding of the cannabis system would enable the development of new techniques for the treatment of cardiovascular disorders in the future. This article aims to review the role of cannabinoids to pave a future in the treatment and prevention of cardiovascular disorders.

Keywords

Support