Research and Reviews: A Journal of Toxicology
Volume 7, Issue 1 (2017)
Published
Table of contents
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Role of Endogenous and Exogenous Glutathione in the Detoxification of Free Radicals
Abstract: The aging process and disease progression are the result of cellular damage by free radicals. Our first lines of defense against free radical damage are the antioxidants. They are critical for keeping optimal health and wellbeing. The need for antioxidants becomes more critical with increased exposure to free radicals. Pollution, drugs, cigarette smoke, illness, stress, and even exercise can increase free radical exposure. The accumulation of free radicals produced from …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 1–14 Read article
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A Study of Cranio-Facial Injuries in Medico-Legal Autopsies
Abstract: Injury to the cranium and face is a common finding in medico-legal autopsies. Blunt trauma to the cranium is most frequently caused by road traffic accidents, assaults, falls from height and also from impacts by machineries. However, road traffic accidents accounts for the commonest occurrence of cranio-facial injuries. International labour organization 1994 estimated that nearly 2 lacks workers die annually and 1200 lacks are injured. Studies of traumatic cranial injuries …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 15–18 Read article
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A Study of Allege Rape Cases in Barpeta District, Assam
Abstract: Sexual violence regarded as a global problem, not only in the geographical sense but also in terms of age and sex. This study was carried out in the Department of Forensic Medicine, Fakhruddin Ali Ahmed Medical College and Hospital (FAAMCH), Barpeta, Assam, India. A total 580 alleged rape cases coming for examination from different part of Barpeta district of Assam in the year 2014 and 2015 were studied and data …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 19–24 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Thymoquinone Induces Epigenetic Modulation in ROS Dependent Manner
Abstract: Traditional drugs have the ability to treat broad range of diseases by modulating the signaling pathwaysof inflammatory diseases and cancer. Epigenetic modulation is also one of the mechanisms already established as a process of action. Histone deacetylase (HDAC) inhibition leads to changes in gene expression promoting cell death. Thymoquinone (TQ), a bioactive compound from Nigella sativa seeds has shown to have an antineoplastic effect in many cancers. Here we have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 32–39 Read article