Research and Reviews: A Journal of Toxicology
Volume 2, Issue 3 (2012)
Published
Table of contents
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Adverse Events Associated with Oral First-in-Man Administration of New Chemical Entities Compared with Placebo – An Analysis of 14 Single- and Multi-Dosing, Double-Blind, Placebo-Controlled Studies
Abstract: This investigation is a retrospective analysis of the adverse events (AEs) associated with oral administration of new chemical entities (NCEs)for the first time in humans. We gathered data from 14 single- and multiple-dosings of FIM NCE studies conducted in our centre over a period of 5 years. In total, 452 subjects were dosed. A total of 2280 doses were administered. Active medication was given on 1763 dosing occasions and placebo …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 3, 2012 · pp. 1–6 Read article
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Solid Waste on GITAM University, Hyderabad Campus - Characterization, Quantification with Projections for Future and Disposal Methods
Abstract: The present study attempted to characterize and quantify the solid waste generated by regular student activities for a fortnight. The solid waste comprised food waste, vegetable peels, solid paper refuse, caps of cool drink bottles, plant twigs, unsorted rubbish and non-biodegradable plastic. The daily solid waste was estimated to be 0.06 ton dry weight. A questionnaire survey on the food preference by the consumers revealed fried items are of major …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 3, 2012 · pp. 15–21 Read article
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Assessment of Suitability of Inland Wetland Fishes in Gujarat, India, for Human Consumption: A Focus on Organochlorine Pesticides
Abstract: The work described in this study evaluated the organochlorine pesticide (OCP) residues in the inland wetland fishes of Gujarat, India, and their suitability for human consumption. Among the various OCPs analyzed, isomers of hexachlorocyclohexane (HCH), γ-HCH and β-HCH were detected in 70%–80% of samples. The p,p’-DDE, metabolites of DDT were detected in higher load. Of the nine species of fishes tested, the maximum load of ∑HCH and ∑DDT was recorded …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 3, 2012 · pp. 7–14 Read article