Research & Reviews: A Journal of Drug Design & Discovery
Volume 6, Issue 1 (2019)
Published
Table of contents
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Drug Discovery and Development: An Overview from the Regulatory Prospective
Abstract: The improvement of medication from an underlying plan to its entrance into the market is an extreme process which can take around 5–10 years and cost $1.7 billion. The thought for another advancement can originate from an assortment of sources which incorporate the flow necessities of the market, new rising infections, good clinical research, business part, and so on. Once an objective for revelation has been picked, the pharmaceutical businesses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 1–9 Read article
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In Silico Designing of Triazolothiadiazine as Anticancer Agents
Abstract: Cancer is irregular growth of cells and formation of tumor. There are approximately 9.6 million death reported globally. It is caused by physical or genetic factor. There are various targets for the inhibition of growth of cancerous cells. Inhibition of colchicines binding site of tubulin is promising target in field of cancer management. In this study, we designed 25 novel thiazole and triazolothiadiazine derivatives as colchicine binding site inhibitors and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 10–20 Read article
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An Insight to Animal Models of Drug Induced Schizophrenia
Abstract: Schizophrenia is a mental disorder that generally shows in early adulthood or late adolescence characterized by hallucinations, delusions, and other cognitive dysfunctions, schizophrenia can often be a lifelong problem. Schizophrenia affects approx. 1% of all adults, universally. The purpose of this article is to review several drug induced schizophrenia animal models. The scientific study of human disorders has required the development of suitable animal models. The prevailing recent view of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 21–33 Read article
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Molecular Docking Technique Assisted Discovery of Some Hydroxylated Chalcone Molecules as α-glucosidase Inhibitors
Abstract: The present study involved exploration of the inhibitory potential of some A-ring hydroxylated chalcone compounds against PDB ID: 2QMJ file (Maltase-glucoamylase in complex with acarbose) with the assistance of iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present study highlighted the immense potentials of several unexplored hydroxyl group (in ring-A) containing chalcones in successfully inhibiting the one of the most effective anti-hyperglycemic based enzymatic target α-glucosidase. The research has …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 34–38 Read article
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Preliminary Phytochemical Investigation of the Leaves and Stem of the Prosopis cineraria (L.) Druce
Abstract: The trees are the greatest gift to the mankind; the civilization on this planet depends on the successful utilization of the plants and the animals for the various purposes. Early man depends on the nature’s mercy and they hunted the animal for the hunger but as the human started the domestication, they use the trees and they observed the natures for the several purposes. The trees are the reservoirs of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 39–43 Read article