Research & Reviews: A Journal of Drug Design & Discovery
Volume 6, Issue 3 (2019)
Published
Table of contents
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Acute Toxicity and Histopathological Evaluation of Polyherbal Formulations of Annona Squamosa, Zingiber Officinalis and Triticum Aestivum in Wistar Rats
Abstract: The relationship between dose and its effects on the exposed organism is of high significance in toxic evaluation. The present study was aimed for the safety assessment of methanolic extract of Annona squamosa, Zingiber Officinalis and Triticum aestivum as polyherbal formulations at different ratios in albino Wistar rats. Sighting study was conducted in one female rat by administering 300 mg/kg body weight of polyherbal formulation through oral gavage. There were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 1–7 Read article
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Formulation and Evaluation of Face Scrub using Mango Seed as Natural Exfoliant
Abstract: In this study, face scrub as oil in water cream with different ratios of mango seed coats’ powder and stearic acid in 12 different batches has been formulated. Also, mango leaves extract has been used as an antioxidant. Particle size of abrasive agent used was within range of 400‑600 um. Prepared face scrub was evaluated by spreadability, total fatty material (TFM), extrudability and pH. Sample formulation scrub for stability testing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 12–17 Read article
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Review on Zebrafish Model: A Novel Research Tool
Abstract: Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from South Asia. The ease of care, year‐round prolific breeding, and transparent, external development have made these fish a popular model vertebrate for many fields of biology. Over the past 40years, the development methods for genetics, CNS system, CVS system and cancer and other researches have shown rapid development. This review provides an orientation to the zebrafish as a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 18–30 Read article
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Synthesis, Characterization and Biological Evaluation of Some Novel Phenazine Derivatives
Abstract: Novel phenazine analogues (PZ1‑PZ6) were synthesized, characterized by the spectral analysis and screened for anti-arthritis activity by bovin serum and egg albumin protein denaturation method. The synthetic route involves the equimolar mixture of ortho-phenylenediamine and ammonium persulphate which were dissolved in 1 M HCl to give 2,3-diaminophenazine(I). Different substituted aromatic aldehydes were added to the 2,3-diaminophenazine(I) and dissolved in methanol. The reaction mixture was stirred for 1‑2 h and then …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 31–37 Read article
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Ethnomedicinal Importance of Nyctanthes Arbor-Tristis in Ranchi District of Jharkhand
Abstract: Nyctanthes arbor-tristis is one of well-known medicinal plants and many of its parts are used to treat different diseases. Nyctanthes arbor-tristis Linn leaves are used broadly in Ayurvedic medicine for the cure of many ailments such as obstinate sciatica, malaria, chronic fever, rheumatism and internal worm infections, laxative, diaphoretic, diuretic and as a tonic. Nyctanthes arbor-tristis plants were collected locally in the month of October of the year 2017, from …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 8–11 Read article