Research and Reviews : Journal of Computational Biology
Volume 8, Issue 2 (2019)
Published
Table of contents
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A Consolidated Review on Novel Liquisolid Technique to Enhance Aqueous Solubility of Poorly Water Soluble Drugs
Abstract: Liquid technique is a novel capable method that can change the dissolution rate of water insoluble drugs. Liquid preparations such as solutions or suspensions of water unsolvable drugs in suitable non-volatile liquid vechicles can be transformed into suitable flowing as well as compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit improved release profiles. In this case, even though the drug is in …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 1–4 Read article
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In Silico Analysis of Potential Drug Targets in E. coli as Anticancer Agents
Abstract: Escherichia coli is a bacteria which grows as symbiotic and pathogenic organism in humans that expresses with genes causing several diseases. Manipulation and control of genes of E. coli can become a solution for cure of diseases like cancer. Based on QSAR studies, Partial partial charges are neutral for all selected ligands. The surface area, mass and volume for Capsaicin is predicted more compared to other selected ligands. As the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 10–18 Read article
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Solubility Enhancement of Paracetamol by Mixed Solvency Method
Abstract: The aim of this research work was to increase the solubility of poorly water soluble drugs by the mixed solvency method. This method is used for the proper pharmacological response. There are some techniques used for enhancing the solubility of poorly water soluble drugs. The recent trend possess that hydrotropic solution having high demand in industry because of some of its ideal features like easily available, having good recovery, does …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 19–22 Read article
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Anthrax Toxin Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis
Abstract: Anthrax toxin is a three-protein exotoxin that is secreted by the bacterium's virulent strains, the anthrax causative agent Bacillus anthracis. Harry Smith first found the toxin in 1954. Anthrax toxin consists of a protein called a protective antigen (PA) binding cell protein and two enzyme parts called an edema factor (EF) and a deadly factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 23–51 Read article
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Computational Software Assisted Multiple Therapeutic Targets Oriented Screening of Some Natural Alkaloid Compounds
Abstract: The current efforts endeavor towards the computational exploration of some interestingpharmacological potentials of some natural alkaloids by using the Schrodinger Maestro 9.1software. The excellence in therapeutics was screened against five most imperative targets:Cyclin-Dependent Kinase-5 (anti-cancer), Cycloxygenase-2 (anti-inflammatory), Proteinkinase C (anti-cancer), Dipeptidyl peptidase (anti-diabetic), and Angiotensin-1-ConvertingEnzyme (anti-hypertensive). The alkaloids which were previously reported to possessantibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Mycobacteriumsmegmatis and anti-photo-oxidative, have now perceived to be multi-dimensional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 5–9 Read article