Research and Reviews : Journal of Computational Biology
Volume 11, Issue 03 (2022)
Published
Table of contents
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Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
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Integrating Network Pharmacology And Molecular Docking To Investigate The Possibility Of Rutin Against Gout
Abstract: Objective: Gout is an arthritic condition resulting from the deposition of monosodium urate crystals in and around the joints. Rutin, a bioflavanoid or a plant pigment that is mainly found in vegetables and fruits.It is widely known for its anti-inflammatory and antioxidant activity.Hence this research paper proposes the use of an integrated approach of network pharmacology and molecular docking to investigate the potential of Rutin as a treatment option for …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 14–27 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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A Secure System of Health Care Service
Abstract: A Secure System of Health Care Service is a platform that stores patient information in an orderly way to aid in proper patient diagnosis and treatment. The current manual system has various issues, including: Delayed patient record retrieval, The duplicated records of patients, A lack of safety and Ineffective backup procedures for medical records. Although the Internet has long served as a reliable source of medical information, only recently has …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 43–49 Read article
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Development of Intensity-based Segmentation Technique for Meningioma Tumor Detection in MRI Images
Abstract: There are many types of brain tumors. Some brain tumors detection system using segmentation and classification of MRI images. Brain tumors can have any shape or cut. This encourages us to use high-capacity deep neural networks. Segmentation task and 8000 images for classification task of our neural network and found the best architecture to use. convolutional neural network. In recent years, the three most common forms of brain tumours—glioma, meningioma, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 50–54 Read article