Research and Reviews : Journal of Computational Biology
Volume 12, Issue 1 (2023)
Published
Table of contents
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Molecular Docking of Compounds against Dengue Virus Serotype 2 and Prediction of ADME Properties Using Computational Approaches.
Abstract: Objective: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). It is well known that phytochemicals have a great deal of promise for curing human viral, bacterial, and fungal diseases. The purpose of this research was to develop drugs against the nonstructural protein (NS5) of dengue virus 2 (DENV2).Methods: Five phytochemicals from various medicinal plants were chosen for this research. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 1–11 Read article
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Detection of Cervical Cancer Using lncRNA Expression Data and Detection of Possible Biomarkers with Bagged CART Machine Learning Method
Abstract: Aim: Cervical cancer (CC), one of the most common gynecological cancers, occurs when the cell layer that forms the surface of the cervix turns into abnormal cells. This type of cancer ranks fourth in cancer-related female deaths, and 3.6% of women living in developed countries suffer from this disease, while approximately 15% of women living in underdeveloped countries are exposed to this cancer. The primary means of reducing the high …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 12–20 Read article
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Use of Bioinformatics in Discovery of Extraterrestrial Life
Abstract: Is there life form beyond earth? Since many decades, there has been curiosity in the quest for extraterrestrial life. Bioinformatics is the study of using computational methods to analyze biological data. Technical advancement like bioinformatics has helped in the search of life beyond Earth. Discovering extraterrestrial life forms will provide valuable insights into the evolution of life and the fundamental principles of biology. We may be able to learn more …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 21–25 Read article
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Drug Discovery and Design: Focus on computational approaches used in the discovery and design of new drugs
Abstract: Computational approaches have revolutionized the field of drug discovery and design, offering efficient and cost-effective strategies for identifying and developing new therapeutics. This review article explores the application of computational methods in drug discovery, with a focus on virtual screening techniques, molecular docking, molecular dynamics simulations, and quantitative structure-activity relationship (QSAR) models. Virtual screening plays a crucial role in narrowing down large chemical libraries by utilizing ligand-based and structure-based approaches. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 26–30 Read article
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Bioinformatics Tools and Databases for Functional Annotation of Genomes
Abstract: Functional annotation of genomes plays a crucial role in understanding the functions and characteristics of genes. Bioinformatics tools and databases have greatly contributed to this field by providing valuable resources for gene function prediction, pathway analysis, and comparative genomics. This abstract provides an overview of these tools and databases and highlights their significance in functional annotation. Ensembl is a popular bioinformatics tool that offers comprehensive genome annotation and browsing capabilities. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 31–35 Read article