thyroid hormones
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article