Randomized Controlled Trial
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Prospective Evaluation of the Optimal Concentration and Effect of Epinephrine as an Adjuvant to Local Anesthetics for Prolonging Block Duration and Reducing Systemic Toxicity in Outpatient Surgery
Abstract: Purpose: To evaluate the optimal concentration and effect of epinephrine as an adjuvant to local anesthetics for prolonging block duration and reducing systemic toxicity in outpatient surgery. Methods: The study involved a randomized double-blind clinical trial on 80 adult patients awaiting day-care extremity surgery. The patients were randomly assigned to two groups of equal size. One group, Group E, was given the local anesthetic agent along with epinephrine as an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 64–69 Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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Comparison Of Postoperative Sore Throat Following Endotracheal Intubation With Or Without Water Based Lubricating Jelly
Abstract: Background: Water-soluble lubricant gel (X-Y jelly) was evaluated for its ability to lessen the common throat pain that follows tracheal intubation under general anesthesia. Materials and Methods: scheduled for elective surgery under general anesthesia requiring endotracheal intubation, Were enrolled in a prospective, randomized, double-blind comparative study. They were split evenly into two -member cohorts. One cohort received 3 mL of water-soluble X-Y gel smeared from the cuff tip to 15 …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article