polyvinyl pyrrlidone

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• Published Subscription 23 May 2012

  Dissolution Enhancement in Nano/Micro-Sized Dispersions of Piroxicam with the Novel Polymer Soluplus® and Polyvinyl Pyrrolidone

  By Sandeep Patnaik, Muralikrishna Molli, R. Gowrishankar, Tanu Mimani Rattan, K. Venkataramaniah

  Abstract: Piroxicam, a Non-Steroidal Anti-Inflammatory Drug (NSAID), belongs to the class II of the biopharmaceutical classification system (BCS) and thus exhibits poor bioavailability. In an effort to tackle this issue, we report here the comparative properties of the solid dispersions of piroxicam made from a novel graft copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) and the linear polymer polyvinyl pyrrolidone (K 25), both the dispersions synthesized identically using solvent evaporation method. …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 1, 2012 Read article →