Polyethylene glycol

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• Published Subscription Original Research Special issue 16 Mar 2026

  Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs

  By K. Selvi, Narendra Varma G., Santosh Karajgi, Manisha S. Nangude, Pavan Karkare, Praveena R., Unmesh Madhavrao Joshi, CH Shashi Kumar, R. Roghini

  Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …

  Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article →