Phospholipid Nano Dispersion
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Formulating Self Phospholipids Dispersion of Poorly Water-Soluble Drug to Enhance Oral Bioavailability
Abstract: In present study, self-nano phospholipid dispersion (SNPD) of Simvastatin (SIM) was prepared based on Phosal 53 MCT to improve the oral bioavailability. Ternary phase diagrams were constructed to evaluate the efficient nanoemulsion regions and also for the optimum concentrations of lipid (Phosal 53 MCT) and surfactant (Cremophore RH 40), co-surfactant (Gelucire 50/13) and water in the formulation. The globule size of SNPD batch A was found to be 115.7 nm, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 24–33 Read article