pH-sensitive hydrogel

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• Published Subscription Original Research Special issue 17 Feb 2026

  Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin

  By Akshay Kumar K.S., Suhas Narayan Sakarkar, Vijeta Bhattacharya, Maneshwar Thippani, L. Karpagavalli, Deepha V., Shiny George, Nitin S. Bhajipale, Manish R. Bhise

  Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …

  Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article →