hyperalgesia
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Ethanolic Root Extract of Jatropha curcas L. Relieves Muscle Pain in Rats
Abstract: The roots of Jatropha curcas are used traditionally to treat pain. The present study evaluated the analgesic property of ethanolic extract of Jatropha curcas (JAT) in acute and chronic muscle pain models. Acute muscle hyperalgesia was induced by injecting 3% carrageenan into the gastrocnemius muscles of rats. Twelve hours after the injection, baseline muscle hyperalgesia was measured and the rats were then treated orally with 30, 100 and 300 mg/kg/day …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 2, 2014 · pp. 5–10 Read article
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Ethanolic Root Extract of Jatropha curcas L. Ameliorates Paclitaxel-Induced Neuropathic Pain in Rats
Abstract: Jatropha curcas is a plant used in various parts of the world as food, medicine for pain and biofuel. The present study investigated the potential analgesic properties of ethanolic root extract of J. curcas on paclitaxel-induced neuropathic pain in rats. Neuropathic pain was induced in rats with paclitaxel. Cold allodynia was measured with cold water at 4.5 °C. Mechanical hyperalgesia was measured in the Randall-Sellito test and thermal hyperalgesia evaluated …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 2, 2013 · pp. 10–15 Read article
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Protease activated receptor-2 as an imperative target in nociceptive responses: A minireview
Abstract: PARs (protease-activated receptors) are a family of seven-transmembrane G-protein coupled receptor for proteases from circulation, inflammatory cells and endothelial tissues. To date, four members of PAR family have been cloned, namely PAR1 to PAR4. This minireview focuses on role of PAR2 receptor in inflammatory and nociceptive processes. Numerous studies documented for activation of PAR2 receptors through several proteases suggests its role in pain and inflammation. However, mechanism of PAR2 underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 1, Issue 1, 2011 · pp. 8–13 Read article