ex-vivo permeation

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• Published Subscription Original Research Special issue 26 Mar 2026

  Evaluation of Mucoadhesive Polymers for Nasal Delivery of Herbal Bioactives

  By Dattatray S. Ghotekar, Ramandeep Kaur, Rasika Manoj Rewatkar, Ishita Sharma, Sujata V. Wankhede, Kavitha C, Sanjeev Kumar, Raosaheb Y. Ghegade, Rishi Pal

  Abstract: A study assessed mucoadhesive polymers for intranasal herbal bioactive administration with higher residence time and mucosal permeability. Chitosan, Carbopol® 934P, and HPMC K15M were utilized to manufacture mucoadhesive nasal gels with standardized herbal bioactive fractions. Formulations were examined for pH, viscosity, spreadability, drug content, mucoadhesive strength, in-vitro release, ex-vivo penetration, and short-term stability. All formulations demonstrated a suitable pH for nasal usage and uniform drug content (97.48 ± 1.12% to …

  Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1680–1689 Read article →