Atrial fibrillation

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• Published Open access Original Research 18 May 2026

  Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation

  By Padidam Lakshmi Sravya

  Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …

  Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article →

• Published Subscription Original Research 12 Mar 2025

  Navigating the Principles and Practice of Oral Anticoagulant Therapy: A Comprehensive Healthcare Guide

  By Julliyan Dilleban, Venkateshan Narayanan, Deephiha E, Balakrishnan K, Bhavani Suba Niranjana M, Thenraja S

  Abstract: Oral anticoagulant therapy plays a critical role in the prevention and treatment of thromboembolic disorders, including atrial fibrillation (AF), venous thromboembolism (VTE), and mechanical heart valve replacement. This research article aims to provide a comprehensive overview of the principles and practice of oral anticoagulant therapy, focusing on the mechanisms of action, pharmacokinetics, clinical indications, monitoring, and management of associated complications. The cornerstone of oral anticoagulant therapy includes vitamin K antagonists …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 76–82 Read article →