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Trends in Drug Delivery

Iron Profile in Gestational Diabetes Mellitus

  1. Abdul Naeem Mansoory
  2. Afsana Sheikh
  3. Kusum Bala Jain
  4. Mukesh Vijayvergia
  5. Mohammed Shadab Gouri

Abstract

Background: The precise mechanisms behind the etio-pathogenesis of gestational diabetes mellitus (GDM) are unknown. According to epidemiological evidence, GDM is linked to higher body iron reserves. Higher serum ferritin levels, which are widely employed as a marker of the body's iron store, have been observed in people with diabetes mellitus. The goal of this study was to see if this occurred in GDM women. Materials and Methods: From April 2023 to October 2023, an observational cross-sectional study was carried out. We have collected data from hospital records, diagnosed with GDM and without GDM. Using a blood sample, serum levels of ferritin, iron, total iron binding capacity (TIBC), percentage of transferrin saturation, and C-reactive protein (CRP) were determined. Results: 40 subjects, 20 women with GDM and 20 women without GDM, were observed. The serum levels of iron, ferritin, transferrin saturation, TIBC, and CRP did not differ between those with and without GDM. Significantly positive correlations between serum ferritin and serum transferrin saturation and significant negative correlations between TIBC levels and serum ferritin were found. Conclusions: Women with and without GDM did not substantially differ in terms of serum ferritin or other iron-related markers. According to the findings of this investigation, high serum ferritin levels do not appear to be beneficial as a marker for the development of GDM.

Keywords

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