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18 articles for “viral integration”
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Nutrition Induced Gut Microbiota Modulation in Food Animals: Implications for Viral Susceptibility, Shedding and Transmission Dynamics for Sustainable Development
Abstract: The gut microbiota has emerged as a central mediator linking host nutrition, immune competence, and vulnerability to viral pathogens in food animals. Diet is a primary driver of microbial community structure and function, influencing metabolite production, intestinal barrier integrity, and systemic antiviral immunity. Accumulating evidence indicates that nutrition induced modulation of the gut microbiota can substantially alter viral susceptibility, replication, and shedding patterns, with downstream effects on transmission dynamics within …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 46–56 Read article
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article
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Unraveling Metagenomics: A Comprehensive Diagnostic Approach for COVID-19
Abstract: The COVID-19 pandemic has brought attention to the need for rapid, accurate, and scalable diagnostic techniques. Metagenomics, a powerful technique that enables the comprehensive analysis of genetic material from complex microbial communities, has emerged as a promising diagnostic approach for COVID-19. This article elucidates the principles of metagenomic sequencing, highlighting its ability to detect viral RNA directly from clinical samples without prior knowledge of the pathogen. Furthermore, we discuss the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article
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Genomic Characterization of Emerging Arboviruses in Rural India
Abstract: Arboviruses (arthropod-borne viruses) represent a rapidly evolving group of pathogens responsible for significant morbidity and mortality, particularly in tropical and subtropical regions. Rural India, characterized by dense vector populations, changing ecological patterns, and limited healthcare infrastructure, has become a hotspot for the emergence and re-emergence of arboviral diseases such as dengue, chikungunya, Japanese encephalitis, and more recently, Zika virus infections. Advances in genomic technologies, including next-generation sequencing (NGS), metagenomics, and …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 · pp. 1–8 Read article
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Advances In HIV Research: Epidemiology, Pathogenesis, And Emerging Therapeutic Strategies
Abstract: Human Immunodeficiency Virus (HIV) remains a critical global health concern, infecting millions of individuals each year. The introduction of antiretroviral therapy (ART) has markedly improved disease outcomes by suppressing viral replication, restoring immune function, and extending patient longevity. Despite these advances, the complete eradication of HIV is hindered by the persistence of viral reservoirs, the emergence of drug-resistant strains, and disparities in healthcare accessibility. This review summarizes key developments in …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Review of Current Trends in Vaccine Development against Zoonotic Viruses: Challenges and Innovations
Abstract: The emergence of zoonotic viruses poses a significant threat to global public health, necessitating rapid advancements in vaccine development. This review highlights the current trends and innovative strategies employed in the creation of vaccines against zoonotic pathogens, including but not limited to viruses responsible for diseases such as Ebola, Zika, Nipah, and more recently, SARS-CoV-2. We discuss various vaccine platforms, including inactivated, live attenuated, mRNA, and viral vector vaccines, focusing …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 1–11 Read article
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Disease: A Major Stumbling Block in the Growth of Aquaculture
Abstract: Aquaculture plays a crucial role in ensuring food security, fostering economic development, and providing recreational opportunities worldwide. However, the intensification of aquaculture practices has led to a surge in environmental challenges, including water pollution, soil acidification, eutrophication, chemical contamination, and the spread of diseases. Among these, diseases caused by bacteria, viruses, fungi, and parasites pose significant threats to the sustainability of global aquaculture. Despite the implementation of various diagnostic methods …
Published in International Journal of Marine Life · Vol. 1, Issue 1, 2024 · pp. 25–28 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Common Diseases of Silkworm and Their Management – A Comprehensive Overview
Abstract: Silkworms (Bombyxmori L.), pivotal to the sericulture industry, are susceptible to various diseases that significantly impact cocoon production and quality. Common silkworm diseases include viral, bacterial, fungal, and protozoan infections. Prominent viral diseases, such as nuclear polyhedrosis (NPV) and cytoplasmic polyhedrosis (CPV) often cause mass mortality in larvae. Bacterial diseases, like flacherie, are typically induced by poor hygiene and environmental stress. Fungal infections, including muscardine caused by Beauveria bassiana, proliferate …
Published in International Journal of Insects · Vol. 2, Issue 1, 2025 · pp. 22–28 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article