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3 articles for “temperature-triggered drug release”

• Published Subscription Original Research 16 Jun 2026

  Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors

  By Kavya D, Khanderao Rajaram Jadhav, Suvarna Manoj Bhadane, Sujit Appasaheb Jadhav, Mohit Kumar, Manisha S Nangude, Josef Yakin, Vikrant Kisanrao Nikam, Akshay Kumar K S

  Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …

  Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article →

• Published Subscription Review Article 4 Jun 2026

  Advances in Stimuli-Responsive Smart Drug Delivery Systems: A Systematic Review

  By Sanjana Dinesh Lanjewar, Prajakta Chandrashekhar Dukre, Sangharsh Dinesh Lanjewar, Pravin Suruse

  Abstract: Imagine a world where medicines work smarter, not harder. Stimuli-responsive drug delivery systems (SRDDS) are transforming healthcare by releasing therapeutic agents in response to specific triggers. These triggers can be internal, like changes in pH or temperature, or external, like light or magnetic fields. By leveraging these triggers, SRDDS can optimize treatment and minimize side effects. The potential applications of SRDDS are vast, from cancer treatment to gene delivery and …

  Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Original Research Special issue 5 Sep 2025

  Biodegradable Polymer Nanocarriers Composites for Biomedical Applications

  By Kishor Waghulde, Nangare S. N., G. G. Dongre, Shankar Lal Soni

  Abstract: Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at …

  Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 293–305 Read article →