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7 articles for “spike protein”
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COVID-19: Impact on Human Health
Abstract: Researchers are on the cutting edge of devising the best strategy to combat the SARS-CoV-2 pandemic by studying and exploring the pathogenesis, prevention, and treatment as the world continues to be plagued by an increasing number of confirmed COVID-19 cases. The primary method for detecting the virus is via antigen testing and more accurate molecular tests such as rt PCR using patient samples. The most prevalent treatments for COVID-19 infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 1, 2022 · pp. 1–8 Read article
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SARS-CoV-2 B.1.617.2 (Delta), B.1.617.2.1 (Delta Plus) Variant and Vaccine Strategies
Abstract: In India and other countries throughout the world, the Delta (B.1.617.2) variety has major devastation. First spotted in October 2020, it has already spread to more than 100 nations, prompting WHO to declare it as a worldwide variant of concern (VOC). Sub-lineages of the original B.1.617 variant include Delta (B.1.617.2), Delta plus (B.1.617.2.1), and Kappa (B.1.617.1). Vaccine deployment, safe-distancing, and timely lockdowns significantly reduced COVID-19 hospitalizations and deaths before the …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 3, 2021 · pp. 63–75 Read article
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Description & Prevention of Omicron
Abstract: November 9, 2021, Botswana becomes the first country to recognise it (Nov 11 2021). The new variant (B.1.529) has been represented in 77 countries. Omicron presents 32 changes in spike protein Scribd, restricting the point of interaction with the ACE2 receptor protein. Computational shows and components’ recreation has been applied to investigate the collaboration between the SARS-CoV-2 RBD and the ACE2 receptor. The receptor-binding domain (RBD), which more barely joins …
Published in Research & Reviews: A Journal of Pharmacognosy Read article
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Real Time Characterization of BA.2.86 and Its Variant (JN.1) in Senegal Using Midnight Protocol
Abstract: During the week ending August 13th, 2023, the most prevalent variant of interest (VOI), uploaded to GISAID, was the BA.2.86 variant. This SARS-CoV-2 Omicron lineage was described as the first phylogenetically distinct from the currently circulating SARS-CoV-2 Omicron XBB lineages, including EG.5.1 and HK.3. Compared to the XBB and BA.2 lineages, the BA.2.86 possesses more than 30 mutations in the Spike (S) protein, suggesting a significant potential for immune evasion. …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 16–21 Read article
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Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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COVID-19: An Emerging Global Threat
Abstract: The emergence of COVID-19 in Wuhan, Hubei Province, China in December 2019 has worsened global health worries. It is now declared by World Health Organization (WHO) as a Public Health Emergency of International Concern (PHEIC). Till 22 March 2021, there have been 122,524,424 confirmed cases of COVID-19 globally, with 2,703,620 deaths, and more than 216 countries are suffering from this fatal virus. The transmission of coronavirus occurs via droplets, filthy …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 3, 2021 · pp. 8–19 Read article