Search
4 articles for “replication timing”
-
Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Artificial Intelligence in Cerebellum Activation
Abstract: Neuroscience plays a significant function during the progression of artificial intelligence. It provided inspiration for the development of human-like AI. There are two ways that neuroscience encourages us to develop AI systems. Neural networks that replicate human cognition and those that match the structure of the brain are the two objectives. Neural networks, which draw inspiration from the architecture of the human brain, are the engine behind contemporary artificial intelligence …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 14–26 Read article
-
Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
-
Comparative Study on the Growth and Yield of Ganoderma lucidium Mushroom Cultivated on African Peach (Nauclea diderrichii) and Bush Mango (Endospermum medullosum) Sawdust as Substrates
Abstract: This study was conducted to find out which substrate provides for the best artificial development of G. lucidium. Mango (Mangifera indica) leaves were added to the saw dusts of Nauclea diderrichii and Endospermum medullosum, which were both utilized as substrates for growing. The substrates were inoculated with Ganoderma spawn and then exposed and hydrated to start the fruiting process. Three replications of the process were carried out. It was observed …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 39–45 Read article