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20 articles for “replication timing”
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Determining the Effect of Applying Different type and Rate of NPSB Fertilizers on Yield of Common Bean at Wolaita Zone Boloso Sore Woreda, South Ethiopia
Abstract: The research was conducted to determine effect of different types and rate of NPSB and CU fertilizers on yield of common bean at boloso sore woreda at rain-feid condition for two years (2016 & 2017) at Areka research center, located at an altitude of 1830 masl, latitude 07° 4’ 24’’ N, longitude 37° 41’ 30’’ E, temperature: 20.3° C, rainfall: 1200-1700 mm, soil type: Haplic alisol. A completely randomized block …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 2, 2024 · pp. 1–6 Read article
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Evaluation of Irrigation Regime on Onion Yield in Konta Special Woreda, Ethiopia
Abstract: Irrigation scheduling (when and how much to apply) is the primary tool to improve water use efficiency, increase crop yields, increase the availability of water resources, and contribute positive effect for the quality of soil and ground water. Field experiment was conducted for two consecutive years to determine appropriate scheduling of onion production. The experiments were arranged in randomized complete block design (RCBD) with four treatments (T1 = 125% manageable …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 1, 2025 · pp. 9–14 Read article
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Scientists Reinvent Low Energy Nuclear Reaction (LENR)/Cold Fusion
Abstract: Two of the researchers of The University of Utah, USA in 1989 named Dr. Martin Fleishmann and Stanley Pons declared that they had discovered a sustained nuclear fusion reaction at room temperature during electrolysis experiment that could solve the problem of energy requirement on this planet. The cold fusion reaction, also called low energy nuclear reaction (LENR) takes place at room temperature, unlike conventional fusion reaction where temperature required is …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 3, 2024 Read article
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Computational Simulations in Drug Discovery: Modeling Protein Folding and Drug Binding
Abstract: Computational simulations have become essential tools in drug discovery, offering unprecedented insights into molecular behavior at the atomic level. These simulations, particularly in the domains of protein folding and drug binding, allow for the exploration of complex biological systems that are often difficult to study experimentally. Protein folding, a critical aspect of drug discovery, involves the transition of a polypeptide chain from an unfolded to a biologically active structure. Understanding …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 23–29 Read article
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Comparison of Models of Machine Learning and Hyperparameter optimization methods on various datasets
Abstract: The most likely phase in achieving powerful and robust machine learning models is probably the hyperparameters tuning step. The traditional exhaustive methods of search (Grid Search and others) ensure that the search space is covered, but are computationally very inexpensive; random search is less expensive and can still miss good regions; and lastly, the modern model-based and population-based methods (Bayesian Optimization, Tree-structured Parzen Estimator (TPE), Genetic Algorithms) are thought to …
Published in Recent Trends in Programming languages · Vol. 13, Issue 1, 2026 Read article
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Data-Driven Digital Twin Model for Real-Time Strength Estimation in Polymeric Materials
Abstract: The real-time prediction of mechanical properties in polymeric materials is essential for ensuring quality, consistency, and operational efficiency in modern manufacturing systems. As industrial processes become increasingly complex, traditional trial-and-error approaches to material characterization are no longer sufficient to meet the demands of high-throughput production environments. This study introduces a digital twin-integrated machine learning approach for the real-time estimation of tensile strength in polymeric materials by combining simulation-driven insights with …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 246–257 Read article
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A Geospatial Analysis of Correlation Between Built-up Area and Vegetation Coverage using Google Earth Engine in Saint Martin Island, Bangladesh
Abstract: Background: This study explores the complex interconnection between expanding human settlements and fluctuating plant life on the island of Saint Martin, Bangladesh, utilizing cutting-edge geospatial techniques through the open-source Google Earth Engine platform. The rapid population boom in Bangladesh and tourism-fueled development on Saint Martin Island stir serious worries about their ecological consequences. Methods: Remote sensing data sourced from Landsat 5 TM and Landsat 8 OLI/TIRS satellites between 1991 and …
Published in Journal of Remote Sensing & GIS · Vol. 16, Issue 1, 2025 · pp. 21–29 Read article
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Intercropping Legumes Covers with Maize on Soil Moisture Improvement in Selected Dry Land Areas of Basketo Special Woreda’s, Ethiopia
Abstract: In order to increase land productivity, intercropping offers enough flexibility to grow two or more crops at the same time on the same plot of land. The advantages of intercropping systems have not been thoroughly investigated and are supported by available experimental data. The purpose of this study was to assess how intercropping affects soil moisture conservation in places under moisture stress, which affects land productivity. In this study, experimental …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 3, 2024 · pp. 09–18 Read article
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Autonomous Calibration of Medical Devices Using Synthetic Biosignals and Adaptive Learning
Abstract: The accuracy and reliability of modern biomedical diagnostic devices are critically dependent on effective calibration mechanisms capable of handling dynamic physiological and environmental variations. Conventional calibration approaches, which rely on static reference signals and manual adjustments, are inadequate in addressing challenges such as sensor drift, noise interference, motion artifacts, and long-term performance degradation. To overcome these limitations, this research proposes an innovative AI-driven adaptive biosignal simulation and calibration architecture for …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 2, 2026 Read article
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Virtual Job Assistance
Abstract: In today’s competitive job market, interviews are a critical gateway to employment, but many candidates struggle with effective preparation. Traditional methods, such as mock interviews with friends or career counselors, often fail to provide detailed feedback or replicate real-world interview dynamics. The “AI-Powered Virtual Job Interview Simulator” addresses these challenges by leveraging advanced technologies, such as Natural Language Processing (NLP), to create a realistic and engaging environment for interview practice. …
Published in Journal of Mechatronics and Automation · Vol. 12, Issue 3, 2025 · pp. 1–11 Read article
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A Study on Precision Blood Propulsion in Motor-Driven Artificial Hearts
Abstract: The development of biocompatible, energy-efficient pumping mechanisms is pivotal for advancing artificial heart (AH) technology. This study explores a motor-driven centrifugal pump designed to replicate the physiological dynamics of natural ventricles while mitigating complications associated with conventional axial and pulsatile systems. The proposed system employs a brushless DC motor with closed-loop control, integrated with pressure and flow sensors to modulate rotational speed (RPM) and generate biomimetic cardiac output. The suggested …
Published in Trends in Electrical Engineering · Vol. 16, Issue 1, 2025 · pp. 53–59 Read article
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Analysis and Design of Pre-Engineering Building Structure by Using Staad Pro Software
Abstract: The analysis and design of a Pre-Engineered Building (PEB) were conducted using STAAD Pro software, alongside manual calculations for accurate load estimation, to ensure the building's compliance with relevant engineering standards and codes. The evaluation took into account multiple load types, including dead loads, live (imposed) loads, wind loads, and relevant load combinations to replicate actual conditions the structure might face during its lifespan. This comprehensive approach provided a deep …
Published in Recent Trends in Civil Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 1–7 Read article
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Evaluating the Benefits of Lift Procedure for Fistula in Ano: A Peripheral Centre Experience
Abstract: Introduction: Surgery is considered the only definitive treatment for anal fistula. Many surgical techniques have been described. The aim of this study was to communicate the authors’ preliminary experience in the use of a very recent, simplified technique, at a peripheral surgical centre. Patients And Methods: This was a retrospective study of 10 patients of Fistula-in-ano admitted from October 2021 through September 2023. Patients were managed with the ligation of …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 17–20 Read article
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Artificial Intelligence in Cerebellum Activation
Abstract: Neuroscience plays a significant function during the progression of artificial intelligence. It provided inspiration for the development of human-like AI. There are two ways that neuroscience encourages us to develop AI systems. Neural networks that replicate human cognition and those that match the structure of the brain are the two objectives. Neural networks, which draw inspiration from the architecture of the human brain, are the engine behind contemporary artificial intelligence …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 14–26 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Evaluation of Emergency Response Plans in Industrial Environments Using Simulation Techniques
Abstract: Industrial facilities, particularly those in the chemical, manufacturing, and energy sectors, face significant hazards due to their complex operations and the handling of hazardous materials. Ensuring the safety of workers and minimizing the impact of incidents require robust and effective emergency response plans (ERPs). Traditional evaluation methods, such as drills and tabletop exercises, often fall short in replicating the complexities of real-world emergencies. These methods may lack the realism needed …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 3, 2024 · pp. 6–10 Read article
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Comparative Study on the Growth and Yield of Ganoderma lucidium Mushroom Cultivated on African Peach (Nauclea diderrichii) and Bush Mango (Endospermum medullosum) Sawdust as Substrates
Abstract: This study was conducted to find out which substrate provides for the best artificial development of G. lucidium. Mango (Mangifera indica) leaves were added to the saw dusts of Nauclea diderrichii and Endospermum medullosum, which were both utilized as substrates for growing. The substrates were inoculated with Ganoderma spawn and then exposed and hydrated to start the fruiting process. Three replications of the process were carried out. It was observed …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 39–45 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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The Strength of Dry, Fresh and Decomposed Raffia Palm Trunk in the Bioremediation of Oil-based Drill Cutting
Abstract: In this research, the impact of dry drill cuttings and compost tea on the environment's ability to degrade oil-based drill cutting contamination is investigated. The experiment was conducted in the research center located at the workshop of Agricultural and Environmental Engineering Department, Rivers State University, Port Harcourt. Oil-based drill cutting samples were placed in bulk in eleven reactors (T1, T2, T3-T11) with four replications. The original drill cuttings' physiochemical characteristics …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 26–33 Read article