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54 articles for “randomized control studies”
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The Effectiveness of Honey Application for Oral Mucositis in Cancer Patients: A Review of Randomized Controlled Trials
Abstract: Background: Oral mucositis (OM) is a prevalent and distressing adverse outcome of cancer therapies, including chemotherapy and radiation therapy. It is an inflammatory ailment that impacts the mucous membrane inside the mouth, tongue, gums, and throat. OM can cause pain, discomfort, difficulty swallowing, and in severe cases, it can lead to infection and delayed cancer treatment. Although there are various treatments available, such as painkillers, anti-inflammatory drugs, and topical anesthetics, …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 32–39 Read article
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Effect of 940-nm Low-Level Laser Therapy on Tooth Movement Rate during Orthodontic Treatment: A Split-Mouth Double-Blind Randomized-Controlled Trial
Abstract: This study aimed to evaluate the effect of low-level laser with wavelength of 940 nm on acceleration of orthodontic tooth movement. Materials and Methods: This study was a double-blind randomized-controlled trial with split-mouth design. Fifty-five patients whose four first premolars were extracted for orthodontic treatment were randomly allocated to group A (n = 27) and group B (n = 28). Canine retraction was performed using the force of 150 g …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 3, 2024 · pp. 14–20 Read article
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The Hidden Struggle: Premenstrual Depression its Impact on Women’s Health and Management Strategies: A Narrative Review.
Abstract: Background: Premenstrual depression, including Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), represents a significant yet underrecognized contributor to women’s mental health burden. Hormonal fluctuations during the luteal phase interact with neurotransmitter systems, particularly serotonin and GABA, leading to affective and somatic symptoms that impair daily functioning. Objective: This systematic review synthesizes evidence on the prevalence, pathophysiology, psychological impact, and management strategies of premenstrual depression among reproductive-aged women, with particular …
Published in International Journal of Nutritions · Vol. 3, Issue 1, 2026 · pp. 21–32 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Examining the Impact of a Nurse Navigator Program on Anxiety, Psychological Well-being, and Quality of Life in Breast Cancer Patients at a Tertiary Care Hospital in Haryana: A Randomized Controlled Trial
Abstract: Background of study: Breast cancer stands as the leading cancer type affecting women and remains a significant contributor to female mortality. It is a complex ailment influenced by multiple factors. Globally, in 2020, approximately 2.3 million women received diagnoses of breast cancer, resulting in 685,000 fatalities. This condition can profoundly impact various aspects of a person's existence, encompassing physical, psychological, emotional, social, and familial spheres. A notable observation is the …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 31–39 Read article
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Systematic Analysis of the Therapeutic Potential of Bacopa monnieri: A Wonder Therapeutic Plant
Abstract: Bacopa monnieri (L.) Wettst., a well-known perennial creeping herb, native to parts of America, the African subcontinent, and South Asia, had been a well-known nootropic plant, documented in ancient Indian systems of medicine, Ayurveda. The dynamic variations in the phytocompounds consortia, regulated by abiotic cultivation conditions and germplasm, provided a paradigm shift towards the exploring profound therapeutic effect of the plant along with advancements in scalable cultivation strategies. Tailoring the …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications
Abstract: Total Knee Replacement (TKR) is a widely used surgical intervention for patients with knee osteoarthritis and other degenerative knee disorders, offering significant improvements in pain relief, functional restoration, and quality of life. This systematic review synthesizes data from multiple clinical studies to evaluate the outcomes and complications associated with TKR. To find applicable research published in the last ten years, a thorough search of electronic databases was performed. Randomised controlled …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 41–56 Read article
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Evaluating the Role of Apple Cider Vinegar in Managing Semaglutide-Induced Gastrointestinal Disturbances: A Systematic Review
Abstract: Background: Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is highly effective in treating type 2 diabetes and obesity. However, its use is often associated with gastrointestinal side effects, including nausea, vomiting, and diarrhea, which may impact patient compliance. Objective: This systematic review aims to evaluate the evidence regarding the management of semaglutide-induced GI symptoms and assess the potential role of apple cider vinegar (ACV) as a complementary treatment. Methods: A …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 1, 2025 · pp. 25–31 Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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Electroconvulsive Therapy in the Management of Schizophrenia: A Systematic Review in Emergency Nursing Practice
Abstract: Electroconvulsive therapy (ECT) is a well-established treatment for various psychiatric disorders, including schizophrenia, particularly in cases where patients are resistant to conventional treatments. Schizophrenia, a chronic and severe psychiatric disorder, often presents with a combination of positive symptoms (such as hallucinations and delusions), negative symptoms (such as social withdrawal and emotional blunting), and cognitive impairments. While antipsychotic medications are the primary treatment, approximately 20–30% of individuals with schizophrenia do not …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 43–48 Read article
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Sudarshan Kriya Intervention and Rise of Protective Prostaglandins in Advanced-Stage Breast Cancer: Double-Blind, Randomized, Controlled Trial
Abstract: Background: Breast cancer patients in advanced stages of cancer are managed by palliative care. This study reports important prostaglandin changes observed with added intervention of Sudarshan Kriya in their ongoing palliative care. Level of Prostaglandin A₂ (PGA₂) indicates tumor growth suppression; its level rises if person’s general condition is good, physically fit and active while PGE₂ and D₂ are considered pro-inflammatory. Quantitative assessment of Prostaglandins was done pre and post …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 62–68 Read article
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Assessing the Increasing Incidence of Prostate Cancer in Urban Delhi: Risk Factors, Early Detection, and Treatment Challenges
Abstract: Background: Prostate cancer has emerged as the second most prevalent cancer among men in India, with rapidly increasing incidence rates in urban areas like Delhi. This rise is attributed to urbanization, lifestyle changes (high-fat diets, tobacco use, sedentary behavior), increased life expectancy, and improved diagnostics. Despite its growing burden, low awareness, limited screening programs, and treatment barriers hinder early detection and effective management. This study examines the epidemiological trends, risk …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 21–28 Read article
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Effect of Valsalva Maneuver Prior to Cannulation on Pain Among Patients Undergoing Peripheral Venous Cannulation
Abstract: Peripheral venous canulation is the common nursing procedure carried out which cause soreness to the recipient. Previous experience of peripheral venous cannulation may result in negligence or delay in need of medical care. Valsalva Maneuver is a non-pharmacological and cost- effective method to decrease intensity of pain during peripheral venous cannulation. Aim: To assess the effect of Valsalva Maneuver prior to cannulation on pain among patients undergoing peripheral venous cannulation. …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 1–6 Read article
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Comparison of Intravenous Lignocaine and Esmolol in Attenuating Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Abstract: Objective: This study aimed to evaluate the effectiveness of intravenous lignocaine versus esmolol in minimizing the hemodynamic response during laryngoscopy and intubation. Methods: This prospective, randomized controlled trial included patients scheduled for elective surgery under general anesthesia. Participants were randomly allocated to receive either intravenous lignocaine (Group L) or esmolol (Group E) prior to induction. Hemodynamic parameters—such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 29–44 Read article
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Evaluating the Impact of the Valsalva Maneuver on Pain Relief During Intravenous Cannulation in Patients at Selected Hospitals in Tirupati, Andhra Pradesh
Abstract: Pain can be defined as an unpleasant tactile sensation, arousing sensory experience, and an emotional response that is linked to any type of tissue, cell, or skin damage. Pain is a very common and a primary reason for which people seek health care. Among all the non-pharmacological methods for pain relieving, the Valsalva maneuver is one of the methods which is found effective in reducing the level of pain a …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 Read article
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A study to assess the effect of nature-based sound therapy during weaning among Mechanically Ventilated patients admitted in intensive care units of a selected tertiary care hospital Ludhiana, Punjab
Abstract: Weaning is a gradual transition from full invasive ventilatory support to spontaneous ventilation with minimal support. This conducted to assess the effect of nature-based sound therapy among Mechanically Ventilated Patients admitted in Intensive Care units. An experimental design (randomized controlled trial) was used to assess the effect of nature-based sound therapy during weaning among Mechanically Ventilated patients.30 patients were drawn from the target population by using convenience sampling technique and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 44–48 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Effectiveness of Video-assisted Teaching on Anxiety Related to Labor Process and Preparation for Labor Among the Primigravida Mothers Attending Antenatal OPD at GMCH-32 Chandigarh
Abstract: Aims and background: A randomized control trial to assess the effectiveness of video-assisted teaching on anxiety related to labor process and preparation for labor among primigravida mothers attending antenatal OPD of GMCH-32, Chandigarh, was carried out in full compliance with ethical standards laid down by the Research and Ethical Committee of GMCH-32, Chandigarh. Method: A systematic random sampling technique was used to select 80 subjects, 40 each in control and …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 9–13 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Red Cell Distribution in Pregnancy Associated with Preeclampsia Patients in Worldwide: A Brief Review
Abstract: Introduction: Preeclampsia (PE) is a major obstetric problem contributing considerably to maternal and prenatal morbidity and mortality worldwide. Preeclampsia varies in incidence in India from 5% to 15%. The role of this hematological parameter in clinical assessment, differential diagnosis, and prognosis evaluation of PE remains unclear. Thus, the purpose of the current review was to investigate the red cell distribution width (RDW) in preeclampsia, analyze its importance for early diagnosis, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 6–12 Read article