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3 articles for “phage lysate”
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Bacteriophage and its Potential for Therapeutic Use in Brucellosis among Cattles
Abstract: Bacteriophages are viruses that can specifically kill certain bacteria. This property of phages can be exploited for therapeutic application in treating bacterial infections in domestic animals. Brucellosis is an important zoonotic disease which is endemic in several countries. Antibiotics are not very effective against bovine brucellosis and the cost of this treatment is very high. Lytic phages against Brucella have been isolated and have been tried for therapy of bovine …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 2, 2021 · pp. 9–17 Read article
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A Single-domain Antibody Cross-reacts with Lipopolysaccharide from Diverse Gram-negative Bacteria
Abstract: Gram-negative bacterial sepsis and endotoxemia are the leading causes of morbidity and mortality in animals and humans worldwide, and attempts have continued to design rational therapies. Endotoxin/lipopolysaccharide (LPS)-neutralizing polyclonal and monoclonal antibodies have been produced, but are not free from problems. Single-domain antibodies (dAbs), constructed from the camelid and the shark ‘heavy chain antibodies’ by phage display technology possess favorable features for in vivo applications. The objective of this study …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 29–37 Read article
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Cloning and Expression of LPS-Binding Single Domain Antibody Clones Selected from Phage Display Library of Indian Desert Camel
Abstract: Despite the absence of light chains in their structure, camelid and shark “heavy chain antibodies” (HCAbs) variable domains (designated as VHH) are able to make functional paratopes. The authors have selected lipopolysaccharide (LPS)-binder “single-domain antibodies” (dAb) clones from the previously constructed phage display library of (LPS)-immunized Indian desert camel. This study was undertaken to make available large amounts of some LPS-binder dAb clones by using a suitable expression vector-host system …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article