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15 articles for “ontology”
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Record Linkage in Knowledge Discovery Process Using Angle Based Machine Learning
Abstract: Record linkage is a critical data cleansing step in the knowledge discovery process, aimed at identifying and resolving inconsistencies across datasets. This study proposes an enhanced record linkage framework tailored for uncertain and large-scale data using a combination of distance measurement, probabilistic modeling, and semantic reasoning. A novel angle-based distance measurement technique is introduced to optimize matching between candidate records. To further boost match accuracy, a Finite Mixture Model (FMM) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1157–1170 Read article
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Enabling Intelligent Interoperability: Advancing Sensor Networks Through the Semantic Sensor Web (SSW)
Abstract: The Semantic Sensor Web (SSW) is an evolution of the traditional Sensor Web, integrating semantic web technologies to enhance the discovery, interpretation, and integration of heterogeneous sensor data. By embedding semantic annotations into sensor observations and metadata, SSW enables automated reasoning, improved interoperability, and more sophisticated querying capabilities across diverse sensor networks. This approach addresses key challenges in handling large-scale, distributed, and dynamic sensor data, particularly in domains such as …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 2, 2025 · pp. 21–37 Read article
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Security of Cloud Computing from a Blockchain Perspective
Abstract: Originally, the foundation of the Internet was trust. There are increased threats and problems after many information disclosures. We have employed even more modern Internet-based devices in recent years. Among the primary issues raised in literature, privacy, data protection, and trust require particular consideration. In this case, a new paradigm for information security has arisen, one that is built on transparency rather than the closed, cryptic methods used in present …
Published in Journal of Advanced Database Management & Systems · Vol. 11, Issue 1, 2024 · pp. 7–11 Read article
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Importance of Thesaurus in Natural Language Processing for Scholarly Data Extraction
Abstract: The exponential growth of scholarly literature needs advanced methods for efficient data extraction and knowledge discovery. Natural Language Processing (NLP) has emerged as a crucial technology in automating the analysis and organization of academic texts. Among various linguistic resources, thesauri serve as important tool for enhancing semantic understanding by providing structured vocabularies, synonyms, and hierarchical relationships between terms. This paper examines the importance of thesauri in enhancing NLP-based scholarly data …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 19–24 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Integrating Digital Twins, Smart Materials, and Human Machine Collaboration for Sustainable Smart Manufacturing: Smart CNC & Industry 4.0 Applications
Abstract: The rapid evolution of Industry 4.0 and the emerging transition toward Industry 5.0 have been catalyzed by the convergence of intelligent digital technologies such as digital twins, cyber–physical systems (CPS), artificial intelligence (AI), the Internet of Things (IoT), and human-in-the-loop (HITL) frameworks. These technologies have transformed traditional manufacturing into adaptive, data-centric ecosystems capable of real-time optimization and predictive decision-making. In recent years, the fusion of computer numerical control (CNC) machines, …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 1–8 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Gene Annotation of Cancer Vaccine for Homo sapiens
Abstract: Objectives: Gene annotation helps us to deduce the structural and functional aspects of a gene that encodes for a functional protein in our body. Thus, by determining the coding sequence and gene location we can derive meaningful insights as to what these genes do in our body. In this study, an unknown gene, cancer vaccine for Homo sapiens has been studied and annotated. Methods: This study was based on a …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 1–14 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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The Evolution and Impact of Numbers: From Ancient Tallies to Quantum Computing: Review Article on Numbers
Abstract: Numbers are among the most fundamental constructs in human civilization, serving as the backbone of mathematics, science, technology, and virtually every aspect of daily life. They represent not only quantities and measures but also relationships, structures, and patterns that underpin the fabric of human understanding. From the earliest tallies etched on bones by prehistoric humans to the sophisticated numerical systems embedded in today’s artificial intelligence and quantum computing, the evolution …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 3, 2025 · pp. 15–19 Read article
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Exploring Artificial Intelligence in Operating Systems for Consumer Enhanced Experience: Knowledge-Based Interfaces for Intelligent User Experience and System Optimization
Abstract: The convergence of knowledge-based systems, machine learning algorithms, and natural language interfaces that provide dynamic and context-sensitive behavior is another foundation for this change. AI-based operating systems are important because they can enhance user experiences via automation, self-optimization, and customization. AI signifies a new era of cognitive computing, from adaptive power management for desktops and embedded systems to predictive text and voice recognition on mobile devices. Furthermore, this ability to …
Published in Journal of Operating Systems Development & Trends · Vol. 12, Issue 3, 2025 · pp. 26–30 Read article
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Physics, Metaphysics, and the Subtle Sciences: A Dialogue between Indigenous Worldviews and Microvita Theory
Abstract: This paper explores the convergence of physics, metaphysics, and subtle sciences through a comparative analysis of indigenous knowledge systems and P.R. Sarkar’s Microvita Theory. Indigenous worldviews across various cultures articulate a holistic understanding of reality in which consciousness, matter, and life processes are deeply interconnected. These frameworks increasingly resonate with developments in quantum physics and systems theory that challenge classical mechanistic paradigms. Microvita Theory, introduced by P.R. Sarkar, posits the …
Published in Research & Reviews : Journal of Physics · Vol. 15, Issue 1, 2026 · pp. 1–13 Read article
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article