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3 articles for “microbiome–immune crosstalk”
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article