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5 articles for “glycosylation”
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Advancements in O-Glycosylation Techniques with Diverse Donor Molecules
Abstract: Since the early stages of carbohydrate chemistry, numerous researchers have employed alkynyl glycosyl donors as key reagents in glycosylation reactions. These donors have played a crucial role in facilitating the synthesis of glycosidic bonds, an essential aspect of carbohydrate-based compounds. Over time, various modifications and improvements have been introduced by different research groups to enhance the efficiency, selectivity, and sustainability of glycosylation processes. A major focus has been on designing …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 7–28 Read article
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Progress in the Chemistry of C-Glycosylation in Carbohydrates
Abstract: Glycosylation is an intricate biochemical process where a glycosyl donor and a glycosyl acceptor are combined to form a glycoside. This process involves the creation of new stereogenic centers at the anomeric site of the glycosyl donor, leading to the formation of a diverse array of products. By establishing glycosidic linkages, the synthesis of complex polysaccharides becomes possible, opening doors to the creation of analogues for further exploration of their …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 87–93 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Ayurveda Treatment of Type 2 Diabetes Mellitus WSR Kaphaja Prameha: A Case Study
Abstract: Type 2 diabetes mellitus is highly prevalent in society nowadays. This is result of deranged lifestyle and food habits of present era. It can be corelated with Prameha in Ayurveda, that is mentioned in all ancient texts of Ayurveda. In present case study, a 45 years old obese patient visited Kayachikitsa OPD with complains of lethargy, weakness, excess sleep, lack of sexual desire and calf pain. He was diagnosed to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 1–4 Read article