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2 articles for “drug-resistant TB”

• Published Subscription Review Article 28 Mar 2025

  Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics

  By Shireen Siddique1, Priyanka Sharma

  Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …

  Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article →

• Published Subscription Original Research 17 Feb 2025

  First Insights into Whole Genome Sequencing of the Mycobacterium tuberculosis Complex: Molecular Diversity and Drug Susceptibility Patterns in Senegal

  By Abdou Padane, Seyni Ndiaye, Malle Gueye, Mamadou Nda, Marièma Sarr, Aminata Mboup, Marilyne Aza-Gnandji, Darrel Ornelle Elion Assiana, Ndèye Astou Dabo, Yacine Amet Dia, Mame Sokhna Gueye, Ndeye Ndack Cissé, Bineta Diouf, Joséphine Khady Badiane, Papa Alassane Diaw, Abdoulaye Samba Diallo, Ousmane Diop, Ousmane Diouf, Raghavendra Amachawadi, Fatoumata Ba, Yacine Mar Diop, Souleymane Mboup, Abdoulaye Leye Sarr

  Abstract: Background: We conducted a bibliographic analysis of the Mycobacterium tuberculosis complex (MTBC) in sub-Saharan Africa, which included the analysis of 8,139 genomic sequences from 34 of the 49 sub-Saharan African countries. Notably, only one complete sequence from Senegal was identified, which had been generated in the United States. Our primary objective was to utilize whole genome sequencing (WGS) to detect resistance in anti-tuberculous strains of the MTBC in Senegal. This …

  Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article →