Search
3 articles for “and zinc finger nucleases”
-
Designer Zinc Finger Nuclease: A Versatile Tool for Genome Editing in Animals
Abstract: In this review, is provided an update on the most popular approaches, including zinc finger nuclease (ZFN)-based gene editing by homologous recombination (HR), gene knockout, non-homologous end joining (NHEJ), and gene therapy in mouse. Zinc finger nucleases (ZFNs) are synthetic restriction enzymes evolved by fusing zinc finger that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location. ZFNs are new tools that promise to radically …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 1, 2014 · pp. 24–30 Read article
-
New Wine in Old Wineskin: Progressive Development of Genomic Editing in Bombyx mori
Abstract: The Bombyx mori insect emerging from lepidopteran family is exploited as an important remunerative specie, vis-a-vis as a model organism for scientific findings. It is unequivocally a primal insect model in which genomic altering tool was used to establish a gene function in vitro. A significant milestone in Bombyx genetics is evidenced by contemporary advancement in germline transformation and whole-genome sequencing, producing genetically engineered silkworms (new wine in an old …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 7, Issue 3, 2018 · pp. 17–25 Read article
-
A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article