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2 articles for “Valsartan”

• Published Subscription 14 Aug 2015

  Development and Validation of HPLC Method for Simultaneous Estimation of Cilnidipine and Valsartan in Bulk and Tablet Dosage Form

  By Ritesh P Bhole, Vinayak C. Pawara, Sohan S. Chitlange, Sager B. Wankhede

  Abstract: A simple, sensitive, accurate and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Valsartan and Cilnidipine. The purposed RP-HPLC method utilizes stationary phase and consists of symmetry C18 (250 × 4.6 mm, 5 μm in particle size) with a mobile phase comprising of Acetonitrile: Ammonium Acetate Buffer (75:25%v/v) pH 5.0 adjusted by Triethylamine at a flow rate of 1.0 mL/min, column temperature …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 2, 2015 · pp. 28–36 Read article →

• Published Subscription 13 Jan 2021

  Nitrosamine: The Carcinogenic Impurity in Angiotensin Receptor Blockers

  By Sandip P. Zine, Sayli A. Sawant, Nilesh Mhapankar

  Abstract: Angiotensin II Receptor Blockers (ARBs), commonly known as the Sartans, are used in the treatment of hypertension for a long time. Currently, seven Sartan drugs, i.e. Valsartan, Losartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, and Eprosartan, are in use. Recently, Nitroso impurity was detected in Valsartan active pharmaceutical ingredient, which led to the recall of batches of products containing it. Even in trace amounts, the impurity is said to be a probable …

  Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 36–43 Read article →