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4 articles for “Sitagliptin”
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Method Development and Validation for the Simultaneous Estimation of Ertugliflozin and Sitagliptin in Bulk and Tablet Dosage Form by using HPLC.
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Ertugliflozin and Sitagliptin in bulk and tablet dosage form. Chromatogram was run through DIKMA Spursil C18 column (4.6 mm x 150mm, 3.0 µm). Mobile phase containing KH2PO4: Methanol (45: 55) was pumped through column at a flow rate of 1ml/min. Temperature was maintained at Ambient. Optimized wavelength for Ertugliflozin and Sitagliptin was 225 nm. Retention time of …
Published in Trends in Drug Delivery · Vol. 8, Issue 3, 2023 · pp. 40–49 Read article
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A Study on Safety and Efficacy of Newer Anti-diabetic Drugs (Sitagliptin, Vildagliptin) in Type 2 Diabetes mellitus
Abstract: AbstractType 2 diabetes mellitus accounts for as much as 90% of all cases of diabetes mellitus. India leads the world with largest number of diabetes subjects earning the dubious distinction of being term the “Diabetes Capital of the world”. The present study was aimed to evaluate safe and effective management of type 2 diabetes mellitus patients by using newer anti-diabetic drugs. A total of 81 patients were interviewed; out of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 27–30 Read article
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Antioxidant activity of Passiflora foetida leaf extracts and silver nanoparticles in diabetic induced rats
Abstract: The anti-oxidant system present in our body prevents against the free radicals. Anti-oxidants were glutathione peroxidise,serum catalase,vitamin E, ascorbic acid and superoxide. In our study the plant extract of Passiflora foetidae were used to estimate the antioxidant levels in diet-induced diabetic rats. The mean of glutathione peroxide of normal rats was 92.98±1.65. "The mean of diet-induced diabetic rats was 152.50 ± 1.92*. Diabetic rats treated with sitagliptin and vildagliptin had …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 10–16 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article