Search
6 articles for “PEG-b-PCL”
-
Engineering of PEG-b-PCL/Pluronic F127 Polymeric Composite Micelles for Controlled Co-Delivery of Docetaxel and Curcumin in Prostate Cancer Therapy
Abstract: Polymeric composite nanocarriers made from amphiphilic block copolymers are popular for their customisable architecture, self-assembly behaviour, and drug release control. A PEG-b-PCL/Pluronic F127 micellar composite was developed and tested as a multifunctional nanocarrier for docetaxel and curcumin administration.The amphiphilic block copolymers Pluronic® F127 and PEG-b-PCL were employed to generate polymeric micelles using solvent evaporation-assisted self-assembly. The optimised polymer composite showed good colloidal stability and uniform size distribution with a zeta …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
-
Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article
-
Polymeric Micelles for Medicinal Plant Solubilization and Delivery of Bioactive Compounds
Abstract: This study involved the design, fabrication, and characterization of polymeric micellar nanocomposites utilizing amphiphilic block copolymers to effectively encapsulate and transport hydrophobic phytoconstituents. The selected bioactive molecule is curcumin, a polyphenol with limited water solubility. A polymeric system known as PEG-PCL was utilized to fabricate core-shell nanostructures by a solvent evaporation-induced self-assembly method. The resulting nanocomposites exhibited homogeneity and colloidal stability, characterized by a zeta potential of −18.7 ± 1.4 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 208–219 Read article
-
Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
-
Advances in Biopolymer-Based Surgical Implants: A Polymer Chemistry Perspective
Abstract: Biopolymers have emerged as a promising class of materials for surgical implants due to their biocompatibility, biodegradability, and ability to mimic natural tissue properties. These materials play a crucial role in modern biomedical engineering by reducing adverse immune responses and enhancing tissue integration. This paper explores the role of polymer chemistry in developing biopolymer-based surgical implants, highlighting key polymeric materials. These polymers are making them suitable for diverse biomedical applications. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 1–6 Read article
-
Piezoelectric Nanoparticles Loaded with Curcumin for Cancer Treatment
Abstract: Conventional cancer chemotherapy treatments are often compromised by systemic toxicity which starts from the lack of tumor specificity of administered anticancer drugs. The side effects limit the dose of the drug that can be administrated, making effective cancer treatment difficult. Nanoparticle-based drug delivery has the potential to overcome this challenge by targeted delivery to tumor and taking the advantage of tumor’s natural leaky vasculature to increase the accumulation of drug-loaded …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 6, Issue 2, 2016 · pp. 1–6 Read article