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2 articles for “MUC5AC”
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Flavonoids Regulate Airway MUC5AC Mucin Expression through Modulation of Multiple Signalling Pathways
Abstract: Airway mucus is a component of pulmonary innate immune function and plays very important role in defense against invading pathogenic microbes, chemicals and particles. The protective function of airway mucus is attributed to the viscoelasticity of mucins. Mucins are large glycoproteins play important role in cell–cell adhesion, airways protection, Nuclear-factor kappa B signalling, epidermal growth factor receptor signalling. Eleven mucin genes (among twenty identified mucin genes) have been expressed at …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 3, 2017 · pp. 21–33 Read article
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Flavonoids Attenuate Airway Mucin Expression, Production and Secretion Induced by Various Inducers
Abstract: Muco-obstructive respiratory disease is caused by changing normal biophysical properties of mucus including alteration of mucin concentration, ion composition and airway surface hydration. Flavonoids are one type of polyphenols which regulate mucin gene expression and consequently inhibit mucus secretion. Thus, this review aimed to discuss the effects of different flavonoids on regulation of various airways mucin gene expression and inhibition of the production of a major airway mucin core protein …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 2, 2019 · pp. 1–13 Read article