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1 article for “Immune Tolerance Breakdown”
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Systemic Lupus Erythematosus Revisited: A Milestones in Classification, Mechanistic Insights on Pathogenesis, Diagnosis, and Evolving Treatment Paradigms
Abstract: Systemic lupus erythematosus (SLE) is a prototypic, multi-systemic chronic inflammatory autoimmune disorder characterized by extreme clinical heterogeneity and the potential to involve virtually any organ or tissue. The condition is driven by a fundamental breakdown in immune tolerance, resulting in the overproduction of pathogenic autoantibodies and the formation of immune complexes that precipitate widespread inflammation and organ damage. This review aims to provide an exhaustive synthesis of recent developments in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article