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7 articles for “HeLa cells.”
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Differential Response by Rotenone on Human Trabecular Meshwork and HeLa Cell Lines
Abstract: Cellular response towards a particular stress condition is dependent on a number of factors including genetic makeup, microenvironmental factors, nutrient availability etc. Cells under same stress condition respond differentially and may exhibit pro-apoptotic or anti-apoptotic behavior. Two quite different cell lines—the cancerous cells of HeLa and the Human Trabecular Meshwork (HTM) cell line with very different microenvironmental requirements behave very differently towards oxidative insult due to rotenone. Study of their …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 14–22 Read article
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Arsenic Induced Cytotoxicity Study Against Human Epithelial Carcinoma (HeLa) Cell
Abstract: The present investigation was undertaken to find out the cytotoxic effects of various amounts of arsenic exposure to human epithelial carcinoma (HeLa) cell. Cells were treated with a final concentration (0, 10, 20, 30, 40 and 50 µg/l) of arsenite in 5 ml MEM for 24 h where 0 concentration was considered as control. Cell viability was determined by the trypan blue (TB) exclusion test using hematocytometer and automated BIO-RAD …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 1–8 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Synthesis of Silver Nanoparticles from Pseuderanthemum malabaricum and Evaluation of Anticancer Activity
Abstract: The present study was focused on eco-friendly and green approach synthesis of silver nanoparticles using plant extracts of P. malabaricum. The morphological and physical properties of synthesized silver nanoparticles were analyzed using various spectroscopic and microscopic studies such as UV visible spectroscopy, FT-IR, XRD, SEM with EDAX, DLS, Zeta potential and Particle size analyzer. After structural characterization, the synthesized silver nanoparticles were subjected to anti-cancer activity studies against cervical cancer …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 21, Issue 2, 2019 · pp. 31–40 Read article
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Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
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Thymoquinone Induces Epigenetic Modulation in ROS Dependent Manner
Abstract: Traditional drugs have the ability to treat broad range of diseases by modulating the signaling pathwaysof inflammatory diseases and cancer. Epigenetic modulation is also one of the mechanisms already established as a process of action. Histone deacetylase (HDAC) inhibition leads to changes in gene expression promoting cell death. Thymoquinone (TQ), a bioactive compound from Nigella sativa seeds has shown to have an antineoplastic effect in many cancers. Here we have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 32–39 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article