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6 articles for “Genome annotation”
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The Basics of Genomics, Proteogenomics: The Demands and Roles that Proteomics can Fulfil in Genome Annotation
Abstract: The science of genomes: scientists have only recently gone from analysing a few or a limited number of genes at a time to investigating thousands of genes, moving from the study of inheritance units to the investigation of an organism's entire genome. The science of genomes, or "genomics," was originally focused to determining DNA sequences (the nucleotide order on a specific fragment of DNA), but it quickly evolved to a …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 3, 2021 · pp. 10–12 Read article
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Bioinformatics Tools and Databases for Functional Annotation of Genomes
Abstract: Functional annotation of genomes plays a crucial role in understanding the functions and characteristics of genes. Bioinformatics tools and databases have greatly contributed to this field by providing valuable resources for gene function prediction, pathway analysis, and comparative genomics. This abstract provides an overview of these tools and databases and highlights their significance in functional annotation. Ensembl is a popular bioinformatics tool that offers comprehensive genome annotation and browsing capabilities. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 31–35 Read article
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Tools and Techniques for Whole-Genome Alignments
Abstract: The prediction of evolutionary relationships between two or more genomes at the nucleotide level is known as whole-genome alignment (WGA). It possesses characteristics of both gene orthology prediction and collinear sequence alignment. WGAs are useful for genome-wide analyses like phylogenetic inference, genome annotation, and function prediction. So many solutions have been developed despite the fact that this problem is difficult. This article provides an overview of the approaches used to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 2, 2022 · pp. 36–38 Read article
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To Explore and Download the Genome Sequence of Drosophila Melanogaster at NCBI
Abstract: Drosophila melanogaster is one of the most intensively studied organisms in biology, serving as a model system for many developmental and cellular processes shared by higher eukaryotes, including humans. A shotgun whole-genome sequencing strategy was used to sequence almost the entire nucleotide of the approximately 120-megamegabase euchromatic portion of the Drosophila genome. It is supported by extensive clone-based sequences and high quality bacterial artificial chromosome maps. Work is being done …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 3, 2021 · pp. 4–6 Read article
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Unveiling Actionable Pathogenic Genes for Precision Oncology in Brain Cancers: Glioblastoma and Astrocytoma
Abstract: Glioblastoma (GBM) and astrocytoma are aggressive primary brain tumors characterized by significant molecular heterogeneity, complicating effective treatment. This study employed targeted next-generation sequencing of 529 cancer-associated genes on matched tumor-normal pairs from GBM and astrocytoma patients. Somatic variants were identified using a rigorous bioinformatic pipeline adhering to GATK Best Practices, with variant allele frequencies (VAF) calculated to assess clonal dominance. Functional annotation and driver mutation classification were performed using Ensemble …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 43–59 Read article
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Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article