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2 articles for “Depot Drug”

• Published Ahead of print Open access Article 27 Jan 2023

  HPLC and Tandem MS Device for the Recognition of Emtricitabine and Tenofovir Alafenamide in K2EDTA Human Plasma Utilizing Emtricitabine 15ND2 Tenofovir D5 as an IS

  By Arnav Walia, Mansingh Rajput, Neel Lahoti, Vinayak Bhosale, Arif Khan, Rishikesh Yadav, Snehal Patil

  Abstract: Developed very impressionable, discriminating, and exact extreme-efficiency liquid chromatographytandem bulk spectrometry form for measurement of Emtricitabine and Tenofovir Alafenamide in human plasma. Emtricitabine15ND2 Tenofovir D5 was used as a within the standard (IS). The samples were divided on Phenomenex Kinetex C18 5 μm 100A, 100*4.6 mm procession utilizing Acetonitrile: 0.2% formic acid, 60:40 V/V as movable state, the retention period of Emtricitabine: 1.36 minutes (±0.5 minutes), Emtricitabine 15ND2: 1.36 minutes …

  Published in Research and Reviews: A Journal of Toxicology Read article →

• Published Subscription Review Article 2 May 2026

  Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives

  By Tejaram Choudhary, Firoz Ahmed, Tanya Sharma, Kamalesh Mistry

  Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article →