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31 articles for “DNA damage”
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Evaluation of Gamma Radiation Induced DNA Damage in Bombyx mori, using Single Cell Gel Electrophoresis (Comet Assay)
Abstract: Bombyx mori (B. mori) is the model insect used in the present study, which is commercially important compared to other Lepidopterans. Eggs of late embryonic stage (7 day old) of B. mori were exposed to different doses of gamma radiation to study the extent of DNA damage using comet assay which is a rapid technique to study the genotoxic effects. Test samples were exposed to varied doses of radiation (100, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Comparative Evaluation of Genotoxicity in Peripheral Blood Mononuclear Cells in Oral Precancer and Cancer Patients Using Single Cell Gel Electrophoresis
Abstract: In the present study the comet assay was performed in peripheral mononuclear cells to evaluate DNA damage among tobacco chewers and smokers. The assay provides a quick, accurate and sensitive way to detect various forms of DNA damage in individual cells. The study comprises 50 oral cancer patients, 12 oral submucous fibrosis patients and 10 healthy controls. The length of the comet tail was used to determine the level of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 26–34 Read article
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Cadmium Accumulation in Different Tissues and DNA Content Alteration in Cat Fish (Clarias batrachus) Exposed to Lethal Concentration of Cadmium
Abstract: In the present study, the acute toxicity experiment was conducted to evaluate LC50 of Cadmium chloride (CdCl2) on Clarias batrachus which was found to be 450 ppm for 96 h. Clarias batrachus (average length of 8.5 ± 0.4 cm and the average weight of 13.5 ± 0.393 g) was exposed to sub-lethal concentration (140 ppm) and lethal (450 ppm) concentrations of Cd for 14 days. The Cd accumulation in tissues …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 1–8 Read article
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The Safety of Dental X-ray Machine against the Deoxyribonucleic Acid (DNA): In Vitro Model Explores the Effects of Chlorine Free Radical, Duration of Exposure and the Doses of Irradiation
Abstract: Background: Patients attended to the dental clinics are referred to X-ray which may arise the possibility of adverse reactions upon oral mucosa. X-ray-induced oral mucosa damage is related to the generation of the free radicals in the aqueous media of the cells. Objectives: This study aimed to clarify the safety of dental X-ray exposure by utilizing an in vitro experimental model of calf-thymus double strands DNA (ctdsDNA) molecule exposed to …
Published in Research and Reviews: A Journal of Dentistry · Vol. 10, Issue 2, 2019 · pp. 23–28 Read article
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Assessment of Micronuclei in the Cultured Peripheral Blood Lymphocytes of Human Volunteers Consuming Various Forms of Tobacco in Mizoram
Abstract: Tobacco consumption is highly prevalent in Mizoram—a northeastern state of India—and it is one of the main causes of high cancer incidence. Peripheral blood was collected from 245 volunteers within the age group of 18–67 years with their informed consent and micronuclei were prepared in cultured lymphocytes by blocking cytokinesis. Binucleated (BN) cells bearing micronuclei were scored blindly under a fluorescence microscope, where a total of 3000 BN cells were …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 2, 2019 · pp. 17–26 Read article
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Assessing Nanomaterial Toxicity and Environmental Behavior: Toward Sustainable and Safe Nanotechnology
Abstract: The rapid advancement of nanotechnology has introduced engineered nanomaterials into diverse sectors including medicine, agriculture, electronics, and consumer products. However, the unique physicochemical properties that make nanomaterials valuable also raise significant concerns about their potential toxicity to human health and ecological systems. This study presents a comprehensive survey-based analysis of 400 respondents from diverse professional backgrounds across seven countries to assess perceptions and understanding of nanomaterial toxicity mechanisms and environmental …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 1–11 Read article
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Nitric Oxide—An Important Biomolecule in Breast Carcinoma
Abstract: Breast cancer represents significant problem of the world. Reactive nitrogen species of which nitric oxide (NO) is important constituent is a free radical gas which is synthesized by nitric oxide synthase (NOS).NO inhibits DNA synthesis and can damage DNA directly by deamination. In this study, NO level was studied in normal, pre- and postoperative cases of breast carcinoma. For this blood samples from 60 breast carcinoma cases were taken along …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 55–59 Read article
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Evolution and Impact of Forensic DNA Typing in Modern Investigation
Abstract: Forensic DNA typing is sometimes called DNA fingerprinting. Immigration, paternity, and criminal investigations use forensic DNA typing. Forensic genetics today includes bodily fluid identification, fast DNA analysis, forensic microbiology, and phenotypic profiling. Human cells contain DNA, a molecular code. Human DNA sequences are 99.9% the same in everyone. Every person has almost 0.1% unique DNA. Forensic experts also worry about this 0.1 percent of DNA that is unique. There are …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 62–66 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Electromagnetic Field Effects on Biological Systems and Safety Evaluation of Microwave Exposure
Abstract: The increasing use of wireless communication systems, radar technologies, and microwave- based devices has raised growing concerns regarding the potential biological effects of electromagnetic fields (EMFs) on living systems. This review paper investigates the interaction between electromagnetic field exposure, particularly in the microwave frequency range, and biological tissues, with a focus on safety implications and risk assessment. Microwave radiation, commonly emitted from mobile phones, Wi-Fi routers, and industrial equipment, can …
Published in Journal of Microwave Engineering and Technologies · Vol. 13, Issue 1, 2026 · pp. 26–33 Read article
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Examining the Role of Synthetic Biology in Cellular Restoration Mechanisms
Abstract: Synthetic biology has emerged as a transformative field with the potential to revolutionize cellular repair mechanisms, offering innovative solutions to repair damaged DNA, stabilize proteins, regenerate tissues, and treat a wide range of diseases. By combining principles from genetic engineering, biotechnology, and computational biology, synthetic biology enables the design of cellular systems capable of performing functions that repair cellular damage and restore normal cellular processes. This article explores the application …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 19–29 Read article
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Induction of G1 Phase Cell Cycle Arrest and Apoptosis in Breast Cancer MCF-7 Cells by Sulphonamide Derivative CID-6861424
Abstract: Breast cancer is most frequently detected and leading cause of cancer death in women worldwide. 80% of the breast cancer are estrogen receptor positive and the presently available drugs are ineffective either due to intrinsic resistance or due to acquired resistance. Sulfonamide compounds are a class of compounds showing activities like, antibacterial, antiviral including antitumor. In the present study we have investigated the anti-cancerous activity of sulfonamide derivative CID-6861424 on …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 2, 2019 · pp. 1–17 Read article
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Organometallic Osmium Compounds in Cancer Therapy
Abstract: The exploration of organometallic complexes with osmium as potential anticancer agents was indeed an area of ongoing research. These complexes were being investigated for their unique properties and mechanisms of action against cancer cells. However, it’s essential to note that the field of scientific research is dynamic, and new findings may have emerged since then. Organometallic complexes with osmium can be designed to exhibit specific features that make them promising …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 01–25 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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Betel Quid without Tobacco: A Threat to Oral Health and Well-being in India
Abstract: Betel quid without tobacco, a popular cultural product across India and other South and Southeast Asian nations, is often consumed for its refreshing stimulant effects during social and religious gatherings. Despite its deep cultural significance, the health hazards of betel quid – especially its strong association with oral cancers – are often overlooked. The International Agency for Research on Cancer (IARC) has identified betel quid as a human carcinogen, and …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 6–16 Read article
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A Comprehensive Review on Male Infertility
Abstract: The failure to attain a clinical pregnancy naturally after one year of unprotected intercourse is termed as infertility. Some of the factors that contribute to Infertility are late marriages, advanced age, genetics and lifestyle to name a few. To tackle this scenario, infertile and sub fertile couples take the aid of assisted reproductive technology. Intra uterine insemination (IUI), In vitro fertilization (IVF), Intra cytoplasmic sperm injection (ICSI), surgical sperm retrieval …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 95–103 Read article
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Carbon Nanoparticles: Occupational Exposure and Genotoxic Effects
Abstract: The field of nanotechnology is revolutionizing today’s era by being the fastest emerging field. Though nanotechnology is the boon to the society, the potential toxicity of these nanoparticles should not be ignored as they can affect anyone from microbes to humans. The main focus of this paper is the toxicity of nanoparticles because people working in these areas, prone to nanoparticles are at high risk due to its toxic property. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 9–26 Read article
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Exposure of Nanoparticle Leads to Health Hazards
Abstract: Nanotechnology is a technique used for the production of materials of the nanoscale level. This is a new development in technology which usually entails some hazards as well as advantage to society. Thus nanomaterials are well known for their various beneficial uses in the medicines, engineering, computer, etc., in spite of that it is associated with many hazards related to human health. The exposure of nanomaterials through dermal contact, inhalation, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 3, 2019 · pp. 7–18 Read article