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5 articles for “COX-3”
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Design and Development of a Low-Cost Quadruped Robot for Educational Robotics Applications
Abstract: The locomotion of the quadruped robots resembles that of four-legged animals and can be used on surfaces that wheeled robots cannot navigate. The paper is a design and development report on a low-cost quadruped robot that has been designed to be used in educational and experimental robotics. The robot is a lightweight and modular robotic system consisting of a combination of mechanical design, embedded control, and wireless communication. The actuation …
Published in International Journal of Manufacturing and Production Engineering · Vol. 4, Issue 1, 2026 · pp. 20–26 Read article
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A summary continuation analysis evaluating the prevalence and predictors of diabetic retinopathy in newly diagnosed type 2 diabetic patients.
Abstract: Context: Diabetic retinopathy (DR), the leading cause of acquired blindness in adults, affects approximately 93 million people globally. It is a serious complication of type 2 diabetes, resulting from prolonged damage to the blood vessels in the retina. Although largely preventable and treatable, DR continues to be the main cause of vision loss among working-age adults and significantly impacts quality of life. While most studies on DR in Nepal have …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 21–30 Read article
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Cucumis Sativus: A Review
Abstract: The family Cucurbitaceae includes the cucumber (Cucumis sativus L.). 30 species of Cucumis are distributed in Africa and Asia. One of the first vegetables to be farmed, cucumbers are native to the tropics. It has almost 3,000 years of historical documentation (Yawalkar, 1985). Widespread cultivation of Cucumis sativus (CS) is found in Bangladesh (including the Chittagong Hill Tracts, Gazipur, Sherpur, Cox's Bazar, Tangail, and other forests), the Indian subcontinent, and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article