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9 articles for “COX-2”
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The Emergence of Coxsackievirus A16 Associated with HFMD Colloquially Termed ‘Tomato Flu’ in India 2022: A Detailed Virological Inspection
Abstract: As the world battles the COVID-19 pandemic and grapples with a concerning spike in monkeypox cases, India has encountered another viral illness dubbed "Tomato Flu." Tomato Flu is a viral disease caused by coxsackievirus A16, which is a highly infectious illness affecting children under 10 years old.. Enterovirus A71, CV-A16, CVA6, and echoviruses are the causes of what is also referred to as hand, foot, and mouth disease (HFMD). The …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 29–40 Read article
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A summary continuation analysis evaluating the prevalence and predictors of diabetic retinopathy in newly diagnosed type 2 diabetic patients.
Abstract: Context: Diabetic retinopathy (DR), the leading cause of acquired blindness in adults, affects approximately 93 million people globally. It is a serious complication of type 2 diabetes, resulting from prolonged damage to the blood vessels in the retina. Although largely preventable and treatable, DR continues to be the main cause of vision loss among working-age adults and significantly impacts quality of life. While most studies on DR in Nepal have …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 21–30 Read article
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A Retrospective Analysis of Resin-Based Polymer Composites and Bioactive Glass-Polymer Hybrids Regarding Secondary Caries and Durability
Abstract: Aim- To compare the 2-year clinical survival and failure modes of a Resin-Based Polymer Composites and BioactiveGlass-Polymer Hybrids in Class I and II posterior restorations. Methods-A total of 550 restorations were placed in adult patients across various private dental practices in India to ensure a diverse clinical demographic. Teeth were randomly assigned and restored with either a hybrid composite (Te-Econom, IvoclarVivadent; n=275) or a Resin-Modified Glass Ionomer Cement (GC Gold …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1089–1095 Read article
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Anti-inflammatory Potentials of Various Oxine Compound Series as Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies
Abstract: The present investigation is an exploration of multiple oxine series in inhibiting crucial anti-inflammatory targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by employing the Glide module of Maestro 9.1 software for induced fit docking (IFD). The study also focuses in exploration towards the essential pharmacokinetic parameters (QPlogPo/w, QPlogS, predicted aqueous solubility, QPPCaco, QPPMDCK, and percentage of human oral absorption). The study highlighted the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 16–23 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Cure Fraction Estimation for Traumatic Lumbar Puncture in Patients with Acute Lymphoblastic Leukemia
Abstract: The foremost aim of this research was to estimate the proportion of long-term survivors for traumatic and bloody lumbar puncture in patients suffering from acute lymphoblastic leukemia (ALL). To decide the resonance point of platelet for predicting traumatic event the receiver operating characteristics curve was used. Logistic regression and Cox proportional hazard regression was used to detect risk factors for the traumatic event and any relapse, respectively. To appraise the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 12–21 Read article
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Effect of Diarrhea at Admission on Time to Recovery in Treatment of Severe Acute Malnourished Children in Inpatient Therapeutic Feeding Program in Tigray Region, Ethiopia
Abstract: The mortality rate in inpatient settings remained unacceptably higher, 20–30% for marasmus and 50–60% for Kwashiorkor. This is due to inappropriate case management and co-morbidities mainly diarrhea. Despite, there was no study conducted to show the effect of diarrhea at admission on the length of time to recovery in the treatment of severe acute malnutrition among children aged 6–59 months and then there is little understanding about this issue. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 5, Issue 2, 2016 · pp. 25–40 Read article
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Low profile L5 and S band Microstrip antenna for IRNSS Application Using Coxial Feed
Abstract: In recent aura, navigation is one the most demanding technology. To increase coverage, gain and bandwidth are more important of any wireless communication systems India has developed its own navigational system called IRNSS which work one two frequency band one is L5 (1.176 GHz) and second one is S band (2.482-2.502 GHz) In this paper we proposed 2 different antenna one for L5 band and second for S band antenna …
Published in Journal of Communication Engineering & Systems · Vol. 8, Issue 3, 2018 · pp. 7–17 Read article