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7 articles for “Barrier Dysfunction”
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
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Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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AI Application in the Creation of Medications for COPD
Abstract: The crippling lung condition known as chronic obstructive pulmonary disease (COPD) is typified by a continuous restriction of airflow, which results in increased respiratory dysfunction and a reduced quality of life. The rising incidence of COPD worldwide emphasizes the pressing need for innovative pharmaceutical approaches to address the illness. Even though COPD care has advanced significantly, most current medications concentrate on symptom relief rather than disease change. This gap in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 01–05 Read article
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Determining the Root Causes of Complications in Hemodialysis Maintenance Therapy
Abstract: As with peritoneal dialysis and kidney transplantation, hemodialysis has been considered one of the most effective therapies for the replacement of kidney function. While this helps to save patients with the disease by decreasing morbidity /mortality/ rates, this medication has some side effects. These may manifest during the dialysis process alongside the ongoing treatment. Avoiding these barriers becomes crucial for improving the patients’ prognosis in this context.We are going to …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 27–47 Read article