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6 articles for “Autophagy”
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Cellular Mechanisms of Autophagy in Carcinogenesis: A Narrative Review
Abstract: Autophagy is a highly conserved lysosomal degradation pathway essential for cellular homeostasis, metabolic adaptation, and survival under stress. In the context of carcinogenesis, autophagy exhibits a paradoxical and stage-dependent role. During early tumor development, autophagy acts as a tumor-suppressive mechanism by limiting genomic instability, oxidative stress, and chronic inflammation. Conversely, in established malignancies, cancer cells exploit autophagy to sustain growth, survive hostile tumor microenvironments, and resist anticancer therapies. Increasing evidence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 23–28 Read article
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Understanding Programmed Cell Death
Abstract: Recent studies emphasize the critical role of various types of programmed cell death (PCD) such as apoptosis, autophagy, pyroptosis, and necroptosis, as well as their respective signaling pathways. These processes are essential for regulating cellular balance, responding to stress, and triggering immune defenses. Apoptosis, commonly known as "cellular suicide," is a tightly controlled mechanism that allows cells to die without inducing inflammation. This process is key for tissue development, immune …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 42–50 Read article
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Fasting as a means of Body Purification
Abstract: Fasting is an important method of cure and body purification in naturopathy. Many ancient texts speak about the benefits of fasting. Fasting has also been linked to religions, so that people should follow fasting. There are various festivals in every religion where fasting is practised like Ekadashi in Hindus, Ramadan in Islam, Lent in Christianity, etc. In modern days intermittent fasting has also come into practise. It is however important …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 · pp. 10–18 Read article
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Intermittent Fasting: Exploring the Benefits and Risks of Intermittent Fasting for Weight Loss and Overall Health
Abstract: Perception in Intermittent Fasting: One novel approach for managing weight is intermittent fasting (IF) which is gaining more popularity in recent days. This research investigates advantages and disadvantages of IF with an emphasis on its impact on metabolic processes, cardiovascular health, cognitive abilities, and changes in hormone levels. Methods: A literature review comprising randomized clinical trials, cohort studies, and meta-analyses of peer-reviewed publications was performed. A resolution was obtained by …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 24–29 Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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A Systematic Review on Diabetic Encephalopathy, Its Type & Biomarkers
Abstract: Diabetes and its complications become a major reason of morbidity and mortality associated with the changes of life style. Diabetic Encephalopathy is one of the complication of Diabetes Mellitus. The aim of this paper is to review the information on Diabetic Encephalopathy with emphasis on its etiology , pathogenesis and its treatment. Diabetic encephalopathy is the condition in which impairment of brain function occur. Diabetic encephalopathy is the complication of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 98–117 Read article