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3 articles for “Atrial fibrillation”
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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Navigating the Principles and Practice of Oral Anticoagulant Therapy: A Comprehensive Healthcare Guide
Abstract: Oral anticoagulant therapy plays a critical role in the prevention and treatment of thromboembolic disorders, including atrial fibrillation (AF), venous thromboembolism (VTE), and mechanical heart valve replacement. This research article aims to provide a comprehensive overview of the principles and practice of oral anticoagulant therapy, focusing on the mechanisms of action, pharmacokinetics, clinical indications, monitoring, and management of associated complications. The cornerstone of oral anticoagulant therapy includes vitamin K antagonists …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 76–82 Read article
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A Combined ECG and PPG Signal Powered Artificial Intelligence-Based Prediction Model for Stroke
Abstract: Stroke is one of the most common causes of morbidity and mortality around the world, and emphasis on prevention and early detection strategies cannot be overstated. This review aims to integrate techniques of artificial intelligence with electrocardiogram and photoplethysmogram signals to enhance stroke prediction and monitoring of cardiovascular health. All in all, the application of artificial intelligence that incorporates machine learning, deep learning, or hybrid models gives robust tools toward …
Published in Journal of Control & Instrumentation · Vol. 16, Issue 2, 2025 · pp. 18–26 Read article