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5 articles for “Airway inflammation”
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Effects of Gypsophila on Airway Inflammation in Guinea pig model of ovalbumin‐induced Asthma
Abstract: To look at how Gypsophlia (GSP) affects airway inflammation in a model of ovalbumin-induced asthma in guinea pigs (OVA).Methods: Using a random number table, sixty healthy female guinea pigs were split into six groups, each consisting of ten rats: the normal control, OVA, and GSP (0.45, 0.9, 1.8, and 3.6 g/kg). The ovalbumin and lipopolysaccharide sensitization approach was used to create the OVA guinea pig model. The GSP groups received …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 17–23 Read article
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The Evolution of Asthma Management: A Comprehensive Analysis of GINA 2024 Guidelines, Endotype-Driven Diagnosis, and Targeted Biologic Intervention
Abstract: Asthma remains a substantial global public health challenge, characterized by heterogeneous airway inflammation leading to variable airflow obstruction. Recent advances in personalized medicine and guideline revisions, notably the Global Initiative for Asthma (GINA) 2024 update, mandate a profound paradigm shift from reliance on short-acting beta2-agonists (SABA) to antiinflammatory reliever (AIR) strategies utilizing inhaled corticosteroid (ICS)-formoterol. This report provides an exhaustive analysis of current asthma epidemiology, molecular pathogenesis distinguishing between Type …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 Read article
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Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A Review
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article
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From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
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In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins
Abstract: Chronic Obstructive Pulmonary Disease or COPD is a pulmonary disease that obstructs airways and alveoli accompanied by respiratory issues like emphysema and bronchitis. This disease is caused mainly by inflammatory responses of the body to foreign particles that enter the respiratory path including tobacco smoke, air pollutants and irritants. The hallmark of COPD is excessive inflammation caused by imbalance in protease anti-protease activity. Proteases like elastase breakdown the ECM of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article