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7 articles for “Aggressive cancer”
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Ovarian Cancer: Understanding Risk Factors, Diagnosis, and Advances in Treatment
Abstract: Ovarian cancer is a leading cause of cancer-related mortality among women worldwide, often diagnosed at advanced stages due to its subtle early symptoms. Ovarian cancer develops due to a combination of factors, including genetics, environmental influences, and hormonal changes. This article explores the pathophysiology of ovarian cancer, highlighting the genetic mutations, such as BRCA1 and BRCA2, that contribute to its development. It also discusses current diagnostic methods, including imaging techniques …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
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A Review of Literature on Breast Cancer: Molecular Insights, Clinical Approaches, and Future Perspectives
Abstract: Breast cancer is the leading cause of morbidity and mortality in women globally. Although both men and women can get the condition, women are more likely to get it, and its prevalence has been rising globally in recent years. The epidemiology, risk factors, pathophysiology, diagnosis, treatment options, and survival rates of breast cancer are all examined in this review of recent research. Breast cancer can show up as a lump …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 15–20 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Hidradenocarcinoma: A Rare Skin Disease
Abstract: Hidradenocarcinoma (HAC) also known as ‘‘sweat gland tumor” is an aggressive, uncommon, highly malignant, adnexal tumor derived from the intradermal duct of eccrine sweat glands. It is said to be aggressive as it has a high risk of local recurrence (50%–75%) and a high potential to metastasize to nearby lymph nodes or to other distant sites. Hidradenocarcinoma has other recognized variants which are known by different names such as Malignant …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 1–12 Read article