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2 articles for “Acute kidney injury”

• Published Subscription Hypothesis 15 Sep 2024

  Butrin Tackles Retinoblastoma – A Clinical Hypothesis †

  By Rakshana Manikandan, M. Mala, G. Manikandan, Prakash Vaithyanathan

  Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …

  Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article →

• Published Subscription Review Article 31 Jan 2026

  Drug Induced Immune Mediated Nephritis: Molecular Mechanism , Pathways and Clinical Implications

  By Prahala P.R, Samina Sameer, Sandra Pillai, Kiran K J, Prasobh G R, Anusha Jasmine, Kanthlal S K

  Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …

  Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article →